Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection

N. Yawata, K. J. Selva, Y. C. Liu, K. P. Tan, A. W.L. Lee, J. Siak, W. Lan, M. Vania, A. Arundhati, L. Tong, J. Li, J. S. Mehta, M. Yawata

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

The most severe form of virus-induced inflammation at the ocular surface is epidemic keratoconjunctivitis (EKC), often caused by group D human adenoviruses (HAdVs). We investigated the dynamics and mechanisms of changes in natural killer (NK) cell types in the human ocular mucosal surface in situ over the course of infection. In the acute phase of infection, the mature CD56 dim NK cells that comprise a major subpopulation in the normal human conjunctiva are replaced by CD56 bright NK cells recruited to the ocular surface by chemokines produced by the infected epithelium, and NKG2A-expressing CD56 dim and CD56 bright NK cells become the major subpopulations in severe inflammation. These NK cells attracted to the mucosal surface are however incapable of mounting a strong antiviral response because of upregulation of the inhibitory ligand human leukocyte antigen-E (HLA-E) on infected epithelium. Furthermore, group D HAdVs downregulate ligands for activating NK cell receptors, thus rendering even the mature NKG2A - NK cells unresponsive, an immune-escape mechanism distinct from other adenoviruses. Our findings imply that the EKC-causing group D HAdVs utilize these multiple pathways to inhibit antiviral NK cell responses in the initial stages of the infection.

本文言語英語
ページ(範囲)159-170
ページ数12
ジャーナルMucosal Immunology
9
1
DOI
出版ステータス出版済み - 1 1 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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