Dynamic compression of single nanochannel confined DNA via a nanodozer assay

Ahmed Khorshid, Philip Zimny, David Tétreault-La Roche, Geremia Massarelli, Takahiro Sakaue, Walter Reisner

研究成果: Contribution to journalArticle査読

27 被引用数 (Scopus)

抄録

We show that a single DNA molecule confined and extended in a nanochannel can be dynamically compressed by sliding a permeable gasket at a fixed velocity relative to the stationary polymer. The gasket is realized experimentally by optically trapping a nanosphere inside a nanochannel. The trapped bead acts like a "nanodozer," directly applying compressive forces to the molecule without requirement of chemical attachment. Remarkably, these strongly nonequilibrium measurements can be quantified via a simple nonlinear convective-diffusion formalism and yield insights into the local blob statistics, allowing us to conclude that the compressed nanochannel-confined chain exhibits mean-field behavior.

本文言語英語
論文番号268104
ジャーナルPhysical review letters
113
26
DOI
出版ステータス出版済み - 12 30 2014

All Science Journal Classification (ASJC) codes

  • 物理学および天文学(全般)

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