Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: A preliminary study of the correlations between quantitative parameters and the clinical stage

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

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Objective: To probe the utility of dynamic contrast-enhanced MRI (DCE-MRI) parameters in assessing the clinical characteristics of oral squamous cell carcinoma. Methods: A total of 85 tumours were included. We applied the Tofts and Kermode model for the DCE-MRI data and obtained three dependent parameters: the influx forward volume transfer constant into the extravascular extracellular space (EES) from the plasma (Ktrans), the fractional volume of EES per unit volume of tissue (ve) and the fractional volume of plasma (vp). We evaluated the correlations between these parameters and the clinical stages. Results: The T stage showed a negative correlation with the Ktrans (r = -0.2272; p = 0.0365), but it did not show a significant correlation with the other parameters. The N stage showed a negative correlation with Ktrans (r = -0.1948; p = 0.0404), and there were significant differences between N1 and N2+3 (0.119 ± 0.027 vs 0.096 ± 0.023 min min-2; p = 0.0198) and between N0 and N2+3 (0.114 ± 0.29 vs 0.096 ± 0.023 min min-2; p = 0.0288). Conclusion: A decrease in the Ktrans at the primary site was found in advanced N stage cases, which might indicate that the hypoxic status cause a high possibility of the metastasis. Advances in knowledge: A decrease in the Ktrans at the primary site suggested the high possibility of an advanced N stage.

本文言語英語
論文番号20140814
ジャーナルBritish Journal of Radiology
88
1050
DOI
出版ステータス出版済み - 6 1 2015

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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