"Dynamic" molecular recognition and chirality segregation utilizing concepts of molecular machines and molecular assemblies

Seiji Shinkai

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)

抄録

The need to measure the concentration of selected ions and small organic molecules in both in vivo and in vitro processes is continuously increasing beyond the borders of various research fields. This need has been fulfilled using "host-guest chemistry", or in general, by the use of "molecular recognition". The basic idea in these research fields was derived from the 1: 1 host-guest interaction based on the "key-and-lock" concept. However, we have experienced that only with this classical concept, more precise, higher-order recognition faces serious difficulty. In this review article, I wish to explain that the introduction of two new concepts, i.e., the dynamic action of molecular systems and the amplification effect of molecular assemblies, overcame the limitation of the "key-and-lock" concept. In fact, we have found that even "complete" chirality segregation can be achieved under optimal conditions.

本文言語英語
ページ(範囲)590-601
ページ数12
ジャーナルProceedings of the Japan Academy Series B: Physical and Biological Sciences
95
10
DOI
出版ステータス出版済み - 2019

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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