Dynamical properties of autoimmune disease models: Tolerance, flare-up, dormancy

Shingo Iwami, Yasuhiro Takeuchi, Yoshiharu Miura, Toru Sasaki, Tsuyoshi Kajiwara

研究成果: Contribution to journalArticle査読

35 被引用数 (Scopus)

抄録

The mechanisms of autoimmune disease have remained puzzling for a long time. Here we construct a simple mathematical model for autoimmune disease based on the personal immune response function and the target cell growth function. We show that these two functions are sufficient to capture the essence of autoimmune disease and can explain characteristic symptom phases such as tolerance, repeated flare-ups and dormancy. Our results strongly suggest that a more complete understanding of these two functions will underlie the development of an effective therapy for autoimmune disease.

本文言語英語
ページ(範囲)646-659
ページ数14
ジャーナルJournal of Theoretical Biology
246
4
DOI
出版ステータス出版済み - 6 21 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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