抄録
Evolutionary concepts such as mutation and selection can be best described when formulated as mathematical equations. Cancer arises as a consequence of somatic evolution. Therefore, a mathematical approach can be used to understand the process of cancer initiation and progression. But what are the fundamental principles that govern the dynamics of activating oncogenes and inactivating tumour-suppressor genes in populations of reproducing cells? Also, how does a quantitative theory of somatic mutation and selection help us to evaluate the role of genetic instability?
本文言語 | 英語 |
---|---|
ページ(範囲) | 197-205 |
ページ数 | 9 |
ジャーナル | Nature Reviews Cancer |
巻 | 4 |
号 | 3 |
DOI | |
出版ステータス | 出版済み - 1月 1 2004 |
All Science Journal Classification (ASJC) codes
- 腫瘍学
- 癌研究