Dynamics of cancer progression

Franziska Michor, Yoh Iwasa, Martin A. Nowak

研究成果: Contribution to journalReview article査読

280 被引用数 (Scopus)

抄録

Evolutionary concepts such as mutation and selection can be best described when formulated as mathematical equations. Cancer arises as a consequence of somatic evolution. Therefore, a mathematical approach can be used to understand the process of cancer initiation and progression. But what are the fundamental principles that govern the dynamics of activating oncogenes and inactivating tumour-suppressor genes in populations of reproducing cells? Also, how does a quantitative theory of somatic mutation and selection help us to evaluate the role of genetic instability?

本文言語英語
ページ(範囲)197-205
ページ数9
ジャーナルNature Reviews Cancer
4
3
DOI
出版ステータス出版済み - 1 1 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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