抄録
Evolutionary concepts such as mutation and selection can be best described when formulated as mathematical equations. Cancer arises as a consequence of somatic evolution. Therefore, a mathematical approach can be used to understand the process of cancer initiation and progression. But what are the fundamental principles that govern the dynamics of activating oncogenes and inactivating tumour-suppressor genes in populations of reproducing cells? Also, how does a quantitative theory of somatic mutation and selection help us to evaluate the role of genetic instability?
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 197-205 |
| ページ数 | 9 |
| ジャーナル | Nature Reviews Cancer |
| 巻 | 4 |
| 号 | 3 |
| DOI | |
| 出版ステータス | 出版済み - 1 1 2004 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research