Dynamics of colorectal cancer

Franziska Michor, Yoh Iwasa, Christoph Lengauer, Martin A. Nowak

研究成果: ジャーナルへの寄稿評論記事

102 引用 (Scopus)

抄録

Colorectal cancer results from an accumulation of mutations in tumor suppressor genes and oncogenes. An additional defining characteristic of colorectal cancer is its genetic instability. Two main types of genetic instability have been identified. Microsatellite instability leads to an increased point mutation rate, whereas chromosomal instability refers to an enhanced rate of accumulating gross chromosomal aberrations. All colon cancer cell lines are genetically unstable. An interesting question is whether genetic instability arises early in tumorigenesis. An early emergence of genetic instability could drive most of the somatic evolution of cancer. Here, we review mathematical models of colorectal tumorigenesis and discuss the role of genetic instability.

元の言語英語
ページ(範囲)484-493
ページ数10
ジャーナルSeminars in Cancer Biology
15
発行部数6
DOI
出版物ステータス出版済み - 12 1 2005

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Colorectal Neoplasms
Carcinogenesis
Clonal Evolution
Chromosomal Instability
Microsatellite Instability
Mutation Rate
Tumor Suppressor Genes
Oncogenes
Point Mutation
Chromosome Aberrations
Colonic Neoplasms
Theoretical Models
Cell Line
Neoplasms
Mutation Accumulation

All Science Journal Classification (ASJC) codes

  • Cancer Research

これを引用

Michor, F., Iwasa, Y., Lengauer, C., & Nowak, M. A. (2005). Dynamics of colorectal cancer. Seminars in Cancer Biology, 15(6), 484-493. https://doi.org/10.1016/j.semcancer.2005.06.005

Dynamics of colorectal cancer. / Michor, Franziska; Iwasa, Yoh; Lengauer, Christoph; Nowak, Martin A.

:: Seminars in Cancer Biology, 巻 15, 番号 6, 01.12.2005, p. 484-493.

研究成果: ジャーナルへの寄稿評論記事

Michor, F, Iwasa, Y, Lengauer, C & Nowak, MA 2005, 'Dynamics of colorectal cancer', Seminars in Cancer Biology, 巻. 15, 番号 6, pp. 484-493. https://doi.org/10.1016/j.semcancer.2005.06.005
Michor F, Iwasa Y, Lengauer C, Nowak MA. Dynamics of colorectal cancer. Seminars in Cancer Biology. 2005 12 1;15(6):484-493. https://doi.org/10.1016/j.semcancer.2005.06.005
Michor, Franziska ; Iwasa, Yoh ; Lengauer, Christoph ; Nowak, Martin A. / Dynamics of colorectal cancer. :: Seminars in Cancer Biology. 2005 ; 巻 15, 番号 6. pp. 484-493.
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