Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice

Fumiko Takayama, Xinwen Zhang, Yoshinori Hayashi, Zhou Wu, Hiroshi Nakanishi

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

The expression of cathepsin S (CatS), a microglia-specific lysosomal cysteine protease in the brain, is regulated by the intrinsic microglial circadian clock. We herein report that the diurnal variation of evoked synaptic responses of cortical neurons disappeared in cathepsin S-deficient (CatS−/−) mice. The dendritic spine density of the cortical neurons was significantly reduced by incubation with a recombinant CatS. Furthermore, CatS−/− mice exhibited impaired social interaction and social novelty recognition in the three-chamber test. These findings indicate that the circadian clock-regulated secretion of CatS from microglia is involved in the diurnal variation of synaptic responses and dendritic spine density through the proteolytic modification of perisynaptic ECM molecules. Therefore, a dysfunction of the diurnal synaptic responses due to CatS deficiency may lead to social behavior abnormalities.

本文言語英語
ページ(範囲)447-452
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
490
2
DOI
出版ステータス出版済み - 8 19 2017

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

フィンガープリント 「Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル