Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis

Masanori Honsho, Yuichi Abe, Yukio Fujiki

研究成果: Contribution to journalArticle

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Background: Physiological significance of plasmalogen homeostasis remains unknown. Results: Elevation of plasmalogens reduced cholesterol synthesis by enhancing degradation of squalene monooxygenase (SQLE), whereas SQLE was stabilized in the absence of plasmalogens. Conclusion: Plasmalogens regulate cholesterol synthesis by modulating the stability of SQLE. Significance: SQLE stability is modulated in response to the cellular level of plasmalogens, in addition to the acute changes of cholesterol level.

元の言語英語
ページ(範囲)28822-28833
ページ数12
ジャーナルJournal of Biological Chemistry
290
発行部数48
DOI
出版物ステータス出版済み - 11 27 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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