Early diagnosis and preventive strategy of corticosteroid induced osteonecrosis in systemic autoimmune diseases

Syuichi Koarada, Yukiko Tokuda, Yukihide Ono, Yuri Sadanaga, Satoko Tashiro, Rie Suematsu, Nobuyuki Ono, Akihide Ohta, Yoshifumi Tada

研究成果: 書籍/レポート タイプへの寄稿

抄録

Osteonecrosis of femoral head (ONF) is one of the serious adverse events in the patients with systemic lupus erythematosus (SLE) associated with corticosteroid therapy. We have reported a multicenter prospective study of prevention of ONF in SLE patients on high doses of corticosteroids using anticoagulant of warfarin. In the diagnosis of ONF, plain radiography and magnetic resonance imaging (MRI) are important. Especially, in early stage of ONF, although the plain radiograph is still normal, evident changes can be seen in MRI. The treatment of ONFremains controversial. Anticoagulants may be useful to prevent ONF. Therefore, early diagnosis and prevention of ONF are critical issues especially in SLE patients. In this chapter, we present the radiological images illustrating osteonecrosis in patients with autoimmune diseases including SLE, and review the strategy to prevent ONF induced by corticosteroids.

本文言語英語
ホスト出版物のタイトルCorticosteroids and Steroid Therapy
ホスト出版物のサブタイトルNew Research
出版社Nova Science Publishers, Inc.
ページ79-100
ページ数22
ISBN(電子版)9781634823333
ISBN(印刷版)9781634823081
出版ステータス出版済み - 4月 1 2015
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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