Early jejunostomy creation in cases of isolated hypoganglionosis: verification of our own experience based on a national survey

Yoshio Watanabe, Wataru Sumida, Hidemi Takasu, Kazuo Oshima, Yutaka Kanamori, Keiichi Uchida, Tomoaki Taguchi

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Purpose: Isolated hypoganglionosis (IH) is a rare disease, with few well-established therapeutic strategies. This study aims to verify our preliminary therapeutic strategies developed to date in a comparison with data obtained from a nationwide survey of congenital-type IH. Methods: Of the 90 registered IH cases assessed in a survey of Japanese pediatric surgical departments, 40 patients who had initially undergone jejunostomy (JE) and 41 treated with ileostomy (IL) were analyzed. Thirteen patients with JE sites located less than 50 cm from the ligament of Treitz were defined as having undergone upper jejunostomy (UJE). Postsurgical plain abdominal X-ray findings and survival rates, estimated using the Kaplan–Meier method, were used to evaluate improvements following stoma creation. Results: Improvements in bowel obstruction were observed in significantly more UJE patients (9/13) than non-UJE patients [20/63 (22 JE and 41 IL cases); p = 0.01]. Furthermore, the JE patients demonstrated a significantly higher survival rate than the IL patients (p = 0.01). Following the completion of the 10-year follow-up period, three JE patients died after undergoing massive bowel resection. Conclusions: To manage IH successfully, patients should undergo JE less than 50 cm from the ligament of Treitz during the neonatal period. Properly managing the distal intestines is important for achieving long-term survival.

元の言語英語
ページ(範囲)1509-1512
ページ数4
ジャーナルSurgery today
45
発行部数12
DOI
出版物ステータス出版済み - 12 1 2015

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Jejunostomy
Ileostomy
Ligaments
Survival Rate
Surveys and Questionnaires
Rare Diseases
Intestines
X-Rays
Pediatrics

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Early jejunostomy creation in cases of isolated hypoganglionosis : verification of our own experience based on a national survey. / Watanabe, Yoshio; Sumida, Wataru; Takasu, Hidemi; Oshima, Kazuo; Kanamori, Yutaka; Uchida, Keiichi; Taguchi, Tomoaki.

:: Surgery today, 巻 45, 番号 12, 01.12.2015, p. 1509-1512.

研究成果: ジャーナルへの寄稿記事

Watanabe, Yoshio ; Sumida, Wataru ; Takasu, Hidemi ; Oshima, Kazuo ; Kanamori, Yutaka ; Uchida, Keiichi ; Taguchi, Tomoaki. / Early jejunostomy creation in cases of isolated hypoganglionosis : verification of our own experience based on a national survey. :: Surgery today. 2015 ; 巻 45, 番号 12. pp. 1509-1512.
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abstract = "Purpose: Isolated hypoganglionosis (IH) is a rare disease, with few well-established therapeutic strategies. This study aims to verify our preliminary therapeutic strategies developed to date in a comparison with data obtained from a nationwide survey of congenital-type IH. Methods: Of the 90 registered IH cases assessed in a survey of Japanese pediatric surgical departments, 40 patients who had initially undergone jejunostomy (JE) and 41 treated with ileostomy (IL) were analyzed. Thirteen patients with JE sites located less than 50 cm from the ligament of Treitz were defined as having undergone upper jejunostomy (UJE). Postsurgical plain abdominal X-ray findings and survival rates, estimated using the Kaplan–Meier method, were used to evaluate improvements following stoma creation. Results: Improvements in bowel obstruction were observed in significantly more UJE patients (9/13) than non-UJE patients [20/63 (22 JE and 41 IL cases); p = 0.01]. Furthermore, the JE patients demonstrated a significantly higher survival rate than the IL patients (p = 0.01). Following the completion of the 10-year follow-up period, three JE patients died after undergoing massive bowel resection. Conclusions: To manage IH successfully, patients should undergo JE less than 50 cm from the ligament of Treitz during the neonatal period. Properly managing the distal intestines is important for achieving long-term survival.",
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AU - Watanabe, Yoshio

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AU - Takasu, Hidemi

AU - Oshima, Kazuo

AU - Kanamori, Yutaka

AU - Uchida, Keiichi

AU - Taguchi, Tomoaki

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N2 - Purpose: Isolated hypoganglionosis (IH) is a rare disease, with few well-established therapeutic strategies. This study aims to verify our preliminary therapeutic strategies developed to date in a comparison with data obtained from a nationwide survey of congenital-type IH. Methods: Of the 90 registered IH cases assessed in a survey of Japanese pediatric surgical departments, 40 patients who had initially undergone jejunostomy (JE) and 41 treated with ileostomy (IL) were analyzed. Thirteen patients with JE sites located less than 50 cm from the ligament of Treitz were defined as having undergone upper jejunostomy (UJE). Postsurgical plain abdominal X-ray findings and survival rates, estimated using the Kaplan–Meier method, were used to evaluate improvements following stoma creation. Results: Improvements in bowel obstruction were observed in significantly more UJE patients (9/13) than non-UJE patients [20/63 (22 JE and 41 IL cases); p = 0.01]. Furthermore, the JE patients demonstrated a significantly higher survival rate than the IL patients (p = 0.01). Following the completion of the 10-year follow-up period, three JE patients died after undergoing massive bowel resection. Conclusions: To manage IH successfully, patients should undergo JE less than 50 cm from the ligament of Treitz during the neonatal period. Properly managing the distal intestines is important for achieving long-term survival.

AB - Purpose: Isolated hypoganglionosis (IH) is a rare disease, with few well-established therapeutic strategies. This study aims to verify our preliminary therapeutic strategies developed to date in a comparison with data obtained from a nationwide survey of congenital-type IH. Methods: Of the 90 registered IH cases assessed in a survey of Japanese pediatric surgical departments, 40 patients who had initially undergone jejunostomy (JE) and 41 treated with ileostomy (IL) were analyzed. Thirteen patients with JE sites located less than 50 cm from the ligament of Treitz were defined as having undergone upper jejunostomy (UJE). Postsurgical plain abdominal X-ray findings and survival rates, estimated using the Kaplan–Meier method, were used to evaluate improvements following stoma creation. Results: Improvements in bowel obstruction were observed in significantly more UJE patients (9/13) than non-UJE patients [20/63 (22 JE and 41 IL cases); p = 0.01]. Furthermore, the JE patients demonstrated a significantly higher survival rate than the IL patients (p = 0.01). Following the completion of the 10-year follow-up period, three JE patients died after undergoing massive bowel resection. Conclusions: To manage IH successfully, patients should undergo JE less than 50 cm from the ligament of Treitz during the neonatal period. Properly managing the distal intestines is important for achieving long-term survival.

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