Early-life Photoperiod Influences Depression-like Behavior, Prepulse Inhibition of the Acoustic Startle Response, and Hippocampal Astrogenesis in Mice

Yusuke Takai, Misato Kawai, Tadashi Ogo, Takashi Ichinose, Shigeki Furuya, Nozomu Takaki, Yukihiro Tone, Hiroshi Udo, Mitsuhiro Furuse, Shinobu Yasuo

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Environmental factors during early life stages affect behavioral and physiological phenotypes in adulthood. We examined the effect of photoperiods during development on neurogenesis and affective behaviors during adolescence/adulthood using C57BL/6J mice. Mice were born and raised until weaning under long-day conditions (LDs) or short-day conditions (SDs), followed by a 12L12D cycle until adulthood. Adult mice born under SD showed a shorter latency to first immobility in the forced swim test when compared with the mice born under LD. The mice born under SD also exhibited significantly lower prepulse inhibition, which is a characteristic of schizophrenia. However, the mice exposed to SD and LD during the prenatal period only did not show differences in prepulse inhibition. At 4 weeks of age, there were less 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus (DG) of the hippocampus of mice born under SD when compared with mice born under LD. Double immunostaining showed that the mice born under SD showed less BrdU/glial fibrillary acidic protein (GFAP, an astrocyte marker) cells when compared with mice born under LD. Furthermore, expression of the glucocorticoid receptor in the DG was higher in mice born under SD, and the photoperiod-dependent changes in the number of BrdU-positive cells in the DG were abolished by administration of RU486, a glucocorticoid receptor antagonist. These results suggest that the photoperiod in early life alters astrogenesis in the hippocampus via the hypothalamic–pituitary-adrenal axis and may relate to affective behaviors in adulthood.

元の言語英語
ページ(範囲)133-143
ページ数11
ジャーナルNeuroscience
374
DOI
出版物ステータス出版済み - 3 15 2018

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Startle Reflex
Photoperiod
Acoustics
Depression
Dentate Gyrus
Deoxyuridine
Glucocorticoid Receptors
Prepulse Inhibition
Parahippocampal Gyrus
Glial Fibrillary Acidic Protein
Neurogenesis
Bromodeoxyuridine
Weaning
Inbred C57BL Mouse
Astrocytes
Hippocampus
Schizophrenia

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Early-life Photoperiod Influences Depression-like Behavior, Prepulse Inhibition of the Acoustic Startle Response, and Hippocampal Astrogenesis in Mice. / Takai, Yusuke; Kawai, Misato; Ogo, Tadashi; Ichinose, Takashi; Furuya, Shigeki; Takaki, Nozomu; Tone, Yukihiro; Udo, Hiroshi; Furuse, Mitsuhiro; Yasuo, Shinobu.

:: Neuroscience, 巻 374, 15.03.2018, p. 133-143.

研究成果: ジャーナルへの寄稿記事

Takai, Yusuke ; Kawai, Misato ; Ogo, Tadashi ; Ichinose, Takashi ; Furuya, Shigeki ; Takaki, Nozomu ; Tone, Yukihiro ; Udo, Hiroshi ; Furuse, Mitsuhiro ; Yasuo, Shinobu. / Early-life Photoperiod Influences Depression-like Behavior, Prepulse Inhibition of the Acoustic Startle Response, and Hippocampal Astrogenesis in Mice. :: Neuroscience. 2018 ; 巻 374. pp. 133-143.
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abstract = "Environmental factors during early life stages affect behavioral and physiological phenotypes in adulthood. We examined the effect of photoperiods during development on neurogenesis and affective behaviors during adolescence/adulthood using C57BL/6J mice. Mice were born and raised until weaning under long-day conditions (LDs) or short-day conditions (SDs), followed by a 12L12D cycle until adulthood. Adult mice born under SD showed a shorter latency to first immobility in the forced swim test when compared with the mice born under LD. The mice born under SD also exhibited significantly lower prepulse inhibition, which is a characteristic of schizophrenia. However, the mice exposed to SD and LD during the prenatal period only did not show differences in prepulse inhibition. At 4 weeks of age, there were less 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus (DG) of the hippocampus of mice born under SD when compared with mice born under LD. Double immunostaining showed that the mice born under SD showed less BrdU/glial fibrillary acidic protein (GFAP, an astrocyte marker) cells when compared with mice born under LD. Furthermore, expression of the glucocorticoid receptor in the DG was higher in mice born under SD, and the photoperiod-dependent changes in the number of BrdU-positive cells in the DG were abolished by administration of RU486, a glucocorticoid receptor antagonist. These results suggest that the photoperiod in early life alters astrogenesis in the hippocampus via the hypothalamic–pituitary-adrenal axis and may relate to affective behaviors in adulthood.",
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AU - Takai, Yusuke

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AU - Ogo, Tadashi

AU - Ichinose, Takashi

AU - Furuya, Shigeki

AU - Takaki, Nozomu

AU - Tone, Yukihiro

AU - Udo, Hiroshi

AU - Furuse, Mitsuhiro

AU - Yasuo, Shinobu

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AB - Environmental factors during early life stages affect behavioral and physiological phenotypes in adulthood. We examined the effect of photoperiods during development on neurogenesis and affective behaviors during adolescence/adulthood using C57BL/6J mice. Mice were born and raised until weaning under long-day conditions (LDs) or short-day conditions (SDs), followed by a 12L12D cycle until adulthood. Adult mice born under SD showed a shorter latency to first immobility in the forced swim test when compared with the mice born under LD. The mice born under SD also exhibited significantly lower prepulse inhibition, which is a characteristic of schizophrenia. However, the mice exposed to SD and LD during the prenatal period only did not show differences in prepulse inhibition. At 4 weeks of age, there were less 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the dentate gyrus (DG) of the hippocampus of mice born under SD when compared with mice born under LD. Double immunostaining showed that the mice born under SD showed less BrdU/glial fibrillary acidic protein (GFAP, an astrocyte marker) cells when compared with mice born under LD. Furthermore, expression of the glucocorticoid receptor in the DG was higher in mice born under SD, and the photoperiod-dependent changes in the number of BrdU-positive cells in the DG were abolished by administration of RU486, a glucocorticoid receptor antagonist. These results suggest that the photoperiod in early life alters astrogenesis in the hippocampus via the hypothalamic–pituitary-adrenal axis and may relate to affective behaviors in adulthood.

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