Early-onset sarcoidosis mimicking refractory cutaneous histiocytosis

Shouichi Ohga, Kiyomi Ichino, Kazunori Urabe, Masataka Ishimura, Hidetoshi Takada, Ryuta Nishikomori, Masutaka Furue, Toshiro Hara

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

A 10-year-old female was diagnosed as having early-onset sarcoidosis (EOS) after a prolonged skin disease. A granuloma emerged on the face at age 2 and massive lesions extended to the rest of the body. Repeated biopsies indicated histiocytic proliferation. At age 7, fever, disseminated macular eruptions, and multinucleated giant cells in the bone marrow prompted vinblastine and prednisolone therapy. Five months after stopping therapy, hypercalcemic crisis occurred along with fever, cytopenias, and interferon-γ-nemia indicating a macrophage activation syndrome. A biopsy of nodules confirmed the diagnosis of sarcoidosis. The atypical EOS should be differentiated from histiocytosis.

本文言語英語
ページ(範囲)723-726
ページ数4
ジャーナルPediatric Blood and Cancer
50
3
DOI
出版ステータス出版済み - 3 2008

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 血液学
  • 腫瘍学

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