Effect of β2-agonists on histamine-induced airway microvascular leakage in ozone-exposed Guinea pigs

Hiromasa Inoue, Hisamichi Aizawa, Koichiro Matsumoto, Mutsumi Shigyo, Shohei Takata, Masato Hara, Nobuyuki Hara

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

β2-adrenergic agonists exhibit antipermeability effects in the airways. However, it is not known whether β2-agonists have this beneficial effect in airway mucosa that is already inflamed. We evaluated the effects of two inhaled β2-agonists, salbutamol and formoterol, on the histamine- induced bronchoconstriction and plasma extravasation in the airways of guinea pigs with or without ozone exposure. Total pulmonary resistance (R(L)) was measured before and after histamine inhalation in anesthetized animals that were pretreated with inhaled salbutamol, formoterol, or saline. Plasma extravasation in the airways was measured using Evans blue dye. In the control animals not exposed to ozone, salbutamol and formoterol each significantly reduced both the histamine-induced bronchoconstriction and the plasma extravasation in the trachea and main bronchi. In the ozone-exposed animals, the increase in R(L) after histamine was greater than that in control animals. Salbutamol and formoterol each significantly reduces histamine-induced bronchoconstriction, even in the ozone-exposed animals. Salbutamol did not affect the histamine-induced plasma extravasation, whereas formoterol reduced the plasma extravasation in the main bronchi, but not in the trachea, of the animals exposed to ozone. These results suggest that the anti-inflammatory properties of formoterol in inflamed airways may contribute to the beneficial effects in the treatment of airway inflammation.

元の言語英語
ページ(範囲)723-727
ページ数5
ジャーナルAmerican Journal of Respiratory and Critical Care Medicine
156
発行部数3 I
DOI
出版物ステータス出版済み - 1 1 1997

Fingerprint

Histamine Agonists
Ozone
Albuterol
Histamine
Guinea Pigs
Bronchoconstriction
Bronchi
Trachea
Evans Blue
Adrenergic Agonists
Inhalation
Formoterol Fumarate
Mucous Membrane
Anti-Inflammatory Agents
Coloring Agents
Inflammation
Lung

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

これを引用

Effect of β2-agonists on histamine-induced airway microvascular leakage in ozone-exposed Guinea pigs. / Inoue, Hiromasa; Aizawa, Hisamichi; Matsumoto, Koichiro; Shigyo, Mutsumi; Takata, Shohei; Hara, Masato; Hara, Nobuyuki.

:: American Journal of Respiratory and Critical Care Medicine, 巻 156, 番号 3 I, 01.01.1997, p. 723-727.

研究成果: ジャーナルへの寄稿記事

Inoue, Hiromasa ; Aizawa, Hisamichi ; Matsumoto, Koichiro ; Shigyo, Mutsumi ; Takata, Shohei ; Hara, Masato ; Hara, Nobuyuki. / Effect of β2-agonists on histamine-induced airway microvascular leakage in ozone-exposed Guinea pigs. :: American Journal of Respiratory and Critical Care Medicine. 1997 ; 巻 156, 番号 3 I. pp. 723-727.
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