Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study

I. Ieiri, W. Goto, S. Higuchi, K. Hirata, A. Toshitani, S. Imayama, Y. Ohyama, H. Yamada, K. Ohtsubo

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)

抄録

The purpose of this study was to assess the possible role of the (R)- and (S)- enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH). About 98% of circulating p-HPPH is in the (S)-form. There were significant differences between patients with and without GH in (R)-p-HPPH level (0.055 vs 0.042 μg·ml-1), both enantiomer/racemate level ratios, and R/S enantiomeric ratio (0.0313 vs 0.0232); an increase in serum (R)-p-HPPH level was observed in patients with GH. In separate experiments, the effect of p-HPPH enantiomers on the proliferation of the normal human dermal fibroblast was studied. The in vitro study showed that (R)-p-HPPH selectively stimulated fibroblast growth. The results suggest that the least abundant metabolite, (R)-p-HPPH, is the most toxic with respect to gingival hyperplasia.

本文言語英語
ページ(範囲)51-56
ページ数6
ジャーナルEuropean Journal of Clinical Pharmacology
49
1-2
DOI
出版ステータス出版済み - 11 1995

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)

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