Effect of a negatively charged lipid on membrane-lacticin Q interaction and resulting pore formation

Fuminori Yoneyama, Kouki Shioya, Takeshi Zendo, Jiro Nakayama, Kenji Sonomoto

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Lacticin Q is an antimicrobial peptide that forms pores on membranes. We investigated effects of negatively charged lipids on the binding and pore formation of lacticin Q with liposomes by surface plasmon resonance analysis and fluorescence dye leakage experiments respectively. Negatively charged lipids accelerated the binding of lacticin Q on the membranes and the resulting pore formation. However, the acceleration was not an essential factor in the killing activity of lacticin Q, since pore-forming activities against electrically neutral and negatively charged liposomes occurred similarly.

本文言語英語
ページ(範囲)218-221
ページ数4
ジャーナルBioscience, Biotechnology and Biochemistry
74
1
DOI
出版ステータス出版済み - 2010

All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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