Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats

Vu Thi Hanh, Weilin Shen, Mitsuru Tanaka, Aino Siltari, Riita Korpela, Toshiro Matsui

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

In the present study, we aimed to evaluate the effect of aging on the absorption of small peptides in spontaneously hypertensive rats (SHRs). Three kinds of dipeptides, glycyl-sarcosine (Gly-Sar), Trp-His, and captopril (a dipeptidomimetic drug), a Gly-Sar-Sar tripeptide, a Gly-Sar-Sar-Sar tetrapeptide, and a Gly-Sar-Sar-Sar-Sar pentapeptide were administered at doses of 10 mg/kg each to 8- and 40-week-old SHRs. The peptides were all detected in their intact forms in the blood. There was a significantly promoted absorption of di/tripeptides in aged SHRs compared with young SHRs. In contrast, the absorption of tetra/pentapeptides was not affected by aging. PepT1 expression in the mid-jejunum was significantly increased in 40-week-old SHRs compared with 8-week-old SHRs, whereas aging did not alter the expression of claudin-1, a tight junction related protein. Thus, the present results suggest that SHR aging may enhance the absorption of di/tripeptides through the enhanced PepT1 transport route, although oligopeptides may be absorbed in an age-independent manner.

元の言語英語
ページ(範囲)5935-5943
ページ数9
ジャーナルJournal of Agricultural and Food Chemistry
65
発行部数29
DOI
出版物ステータス出版済み - 7 26 2017

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Inbred SHR Rats
Rats
Sarcosine
Aging of materials
peptides
Peptides
rats
tripeptides
tryptophyl-histidine
Claudin-1
Tight Junction Proteins
oligopeptides
Oligopeptides
tight junctions
dipeptides
Dipeptides
Captopril
Jejunum
jejunum
Blood

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

これを引用

Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. / Hanh, Vu Thi; Shen, Weilin; Tanaka, Mitsuru; Siltari, Aino; Korpela, Riita; Matsui, Toshiro.

:: Journal of Agricultural and Food Chemistry, 巻 65, 番号 29, 26.07.2017, p. 5935-5943.

研究成果: ジャーナルへの寄稿記事

Hanh, Vu Thi ; Shen, Weilin ; Tanaka, Mitsuru ; Siltari, Aino ; Korpela, Riita ; Matsui, Toshiro. / Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats. :: Journal of Agricultural and Food Chemistry. 2017 ; 巻 65, 番号 29. pp. 5935-5943.
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