Effect of allogeneic hematopoietic cell transplantation for patients with T-prolymphocytic leukemia: a retrospective study from the Adult Lymphoma Working Group of the Japan Society for hematopoietic cell transplantation

Satoshi Yamasaki, Hideaki Nitta, Eisei Kondo, Naoyuki Uchida, Takuya Miyazaki, Ken Ishiyama, Miki Kiyota, Hiroshi Matsuoka, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Atsuta, Junji Suzumiya, Ritsuro Suzuki

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

Alemtuzumab is the treatment choice for patients with T-prolymphocytic leukemia (T-PLL). However, patients with T-PLL have a poor prognosis, and the option of allogeneic hematopoietic cell transplantation (HCT) remains controversial in these patients. This study aimed to analyze the outcomes of allogeneic HCT among patients with T-PLL to identify the potential clinical efficacy of allogeneic HCT. We retrospectively analyzed data from 20 patients with T-PLL, including five patients with complex chromosomal abnormalities at diagnosis who received an allogeneic HCT between 2000 and 2016. The median follow-up of survivors was 51 months in allogeneic HCT from human leukemia antigen (HLA)-matched donors. All five patients with complex chromosomal abnormalities died after allogeneic HCT. Our data suggest that allogeneic HCT from an HLA-matched donor can be considered for patients with T-PLL without complex chromosomal abnormalities. New treatment strategies of allogeneic HCT are required to improve the safety and efficacy of allografting in patients with T-PLL and complex chromosomal abnormalities. Potential approaches that identify patients with T-PLL and complex chromosomal abnormalities for allogeneic HCT with better disease control may allow identification of individuals who are suitable for allogeneic HCT.

本文言語英語
ページ(範囲)2213-2220
ページ数8
ジャーナルAnnals of Hematology
98
9
DOI
出版ステータス出版済み - 9 1 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 血液学

フィンガープリント

「Effect of allogeneic hematopoietic cell transplantation for patients with T-prolymphocytic leukemia: a retrospective study from the Adult Lymphoma Working Group of the Japan Society for hematopoietic cell transplantation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル