Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation

M. Mori, T. Kuwano, T. Kamori, Y. Isozaki, T. Nishihara, N. Yamauchi, M. A. Hattori

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

The ATP-binding cassette subfamily B member 1 (ABCB1) is an efflux transporter that excretes xenobiotics and waste matter. High expression of ABCB1 induced by forskolin (FSK) and rifampicin (RIF) in the bovine blastocysts reportedly improves the cellular quality. In the present study, interferon-α, similar to FSK and RIF, was highly potent in inducing the expression of ABCB1 in the bovine blastocysts but did not exhibit an additive effect with FSK and RIF. Bovine blastocysts stimulated by the combined treatment with FSK, RIF, and interferon-α to express high levels of ABCB1 displayed better freezing resistance as indicated by higher cell numbers in post thawing cultures. On transfer to recipients, such embryos established pregnancies with significantly higher frequencies in repeat breeder cows rather than normal ones.

本文言語英語
ページ(範囲)683-688
ページ数6
ジャーナルTheriogenology
81
5
DOI
出版ステータス出版済み - 3 15 2014

All Science Journal Classification (ASJC) codes

  • 小型動物
  • 食用動物
  • 動物科学および動物学
  • 馬獣医学

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