Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation

M. Mori, T. Kuwano, T. Kamori, Y. Isozaki, T. Nishihara, Nobuhiko Yamauchi, M. A. Hattori

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

The ATP-binding cassette subfamily B member 1 (ABCB1) is an efflux transporter that excretes xenobiotics and waste matter. High expression of ABCB1 induced by forskolin (FSK) and rifampicin (RIF) in the bovine blastocysts reportedly improves the cellular quality. In the present study, interferon-α, similar to FSK and RIF, was highly potent in inducing the expression of ABCB1 in the bovine blastocysts but did not exhibit an additive effect with FSK and RIF. Bovine blastocysts stimulated by the combined treatment with FSK, RIF, and interferon-α to express high levels of ABCB1 displayed better freezing resistance as indicated by higher cell numbers in post thawing cultures. On transfer to recipients, such embryos established pregnancies with significantly higher frequencies in repeat breeder cows rather than normal ones.

元の言語英語
ページ(範囲)683-688
ページ数6
ジャーナルTheriogenology
81
発行部数5
DOI
出版物ステータス出版済み - 3 15 2014

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embryo implantation
forskolin
rifampicin
Colforsin
Rifampin
Blastocyst
Adenosine Triphosphate
blastocyst
cattle
interferons
Interferons
Xenobiotics
xenobiotics
additive effect
thawing
Freezing
transporters
embryo (animal)
freezing
Embryonic Structures

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Equine
  • Food Animals
  • Small Animals

これを引用

Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation. / Mori, M.; Kuwano, T.; Kamori, T.; Isozaki, Y.; Nishihara, T.; Yamauchi, Nobuhiko; Hattori, M. A.

:: Theriogenology, 巻 81, 番号 5, 15.03.2014, p. 683-688.

研究成果: ジャーナルへの寄稿記事

Mori, M, Kuwano, T, Kamori, T, Isozaki, Y, Nishihara, T, Yamauchi, N & Hattori, MA 2014, 'Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation', Theriogenology, 巻. 81, 番号 5, pp. 683-688. https://doi.org/10.1016/j.theriogenology.2013.11.015
Mori, M. ; Kuwano, T. ; Kamori, T. ; Isozaki, Y. ; Nishihara, T. ; Yamauchi, Nobuhiko ; Hattori, M. A. / Effect of ATP-binding cassette subfamily B member 1 on bovine blastocyst implantation. :: Theriogenology. 2014 ; 巻 81, 番号 5. pp. 683-688.
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