Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain

Tatsuo Nakahara, Toshihide Kuroki, Kijiro Hashimoto, Hisao Hondo, Tetsuyuki Tsutsumi, Keisuke Motomura, Hiroshi Ueki, Makoto Hirano, Hideyuki Uchimura

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

The effect of atypical antipsychotics on the immediate-early gene, are (activity-regulated cytoskeleton-associated gene), expression was investigated in phencyclidine (PCP)-treated rats using RT-PCR. Administration of PCP (10 mg/kg) increased arc mRNA levels in the prefrontal cortex, nucleus accumbens and posterior cingulate cortex. Pretreatment with clozapine (20 mg/kg), olanzapine (10 mg/kg) and risperidone (2 mg/kg), but not haloperidol (2 mg/kg), prevented PCP-induced arc expression in the prefrontal cortex and nucleus accumbens. Pretreatment of haloperidol increased the striatal arc mRNA levels. Clozapine, olanzapine and haloperidol inhibited the PCP-induced arc expression in the posterior cingulate cortex. These results suggest that the effects of antipsychotic drugs on PCP-induced arc expression in the prefrontal cortex and nucleus accumbens are useful for distinguishing atypical antipsychotic properties of the drugs. (C) 2000 Lippincott Williams and Wilkins.

本文言語英語
ページ(範囲)551-555
ページ数5
ジャーナルNeuroReport
11
3
DOI
出版ステータス出版済み - 2000

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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