Effect of BAY y 5959 on myocardial function and metabolism in normal and failing hearts

Koji Todaka, Jie Wang, Geng Hua Yi, Anguo Gu, Shu Ming Zhu, Hui Zhang, Daniel Burkhoff

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

BAY y 5959 is a dihydropyridine derivative with positive inotropic actions mediated by a direct increase in intracellular calcium. We characterized the direct myocardial actions of this new agent in hearts isolated from seven normal dogs and from five dogs with repeated coronary microembolization-induced heart failure. Inotropic actions of BAY y 5959 were accompanied by little effect on duration of contraction and by prolongation of the monophasic action potential (MAP); in contrast, isoproterenol decreased contraction and MAP durations. Whereas inotropic responsiveness to isoproterenol was blunted in embolized hearts, these actions of BAY y 5959 were relatively preserved in the heart failure state. Isoproterenol increased heart rate, whereas BAY y 5959 had little effect. Changes in coronary vascular resistance also decreased similarly for isoproterenol and BAY y 5959. Finally, for comparable inotropy, increases in myocardial oxygen consumption were similar for isoproterenol and for BAY y 5959. In summary, preserved inotropic responsiveness and lack of positive chronotropic actions are two clinically favorable features of this type of inotropic agents compared with a typical β-adrenergic agonist.

元の言語英語
ジャーナルAmerican Journal of Physiology - Heart and Circulatory Physiology
274
発行部数5 43-5
出版物ステータス出版済み - 5 1 1998
外部発表Yes

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Isoproterenol
Action Potentials
Heart Failure
Dogs
Adrenergic Agonists
Oxygen Consumption
Vascular Resistance
BAY y 5959
Heart Rate
Calcium

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

これを引用

Effect of BAY y 5959 on myocardial function and metabolism in normal and failing hearts. / Todaka, Koji; Wang, Jie; Yi, Geng Hua; Gu, Anguo; Zhu, Shu Ming; Zhang, Hui; Burkhoff, Daniel.

:: American Journal of Physiology - Heart and Circulatory Physiology, 巻 274, 番号 5 43-5, 01.05.1998.

研究成果: ジャーナルへの寄稿記事

Todaka, Koji ; Wang, Jie ; Yi, Geng Hua ; Gu, Anguo ; Zhu, Shu Ming ; Zhang, Hui ; Burkhoff, Daniel. / Effect of BAY y 5959 on myocardial function and metabolism in normal and failing hearts. :: American Journal of Physiology - Heart and Circulatory Physiology. 1998 ; 巻 274, 番号 5 43-5.
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abstract = "BAY y 5959 is a dihydropyridine derivative with positive inotropic actions mediated by a direct increase in intracellular calcium. We characterized the direct myocardial actions of this new agent in hearts isolated from seven normal dogs and from five dogs with repeated coronary microembolization-induced heart failure. Inotropic actions of BAY y 5959 were accompanied by little effect on duration of contraction and by prolongation of the monophasic action potential (MAP); in contrast, isoproterenol decreased contraction and MAP durations. Whereas inotropic responsiveness to isoproterenol was blunted in embolized hearts, these actions of BAY y 5959 were relatively preserved in the heart failure state. Isoproterenol increased heart rate, whereas BAY y 5959 had little effect. Changes in coronary vascular resistance also decreased similarly for isoproterenol and BAY y 5959. Finally, for comparable inotropy, increases in myocardial oxygen consumption were similar for isoproterenol and for BAY y 5959. In summary, preserved inotropic responsiveness and lack of positive chronotropic actions are two clinically favorable features of this type of inotropic agents compared with a typical β-adrenergic agonist.",
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AU - Todaka, Koji

AU - Wang, Jie

AU - Yi, Geng Hua

AU - Gu, Anguo

AU - Zhu, Shu Ming

AU - Zhang, Hui

AU - Burkhoff, Daniel

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