Effect of cell permeable peptide of c-Jun NH2-terminal kinase inhibitor on the attenuation of renal ischemia-reperfusion injury in pigs

A. Doi, H. Kitada, M. Ota, S. Kawanami, K. Kurihara, Y. Miura, T. Nishiki, Y. Okabe, S. Inoue, M. Tanaka

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

The outcomes of organ transplantation have improved due to better immunosuppressive drugs, surgical techniques, and management of complications. However, ischemia-reperfusion injury remains a challenge affecting graft survival. In this study, we employed injection of a protein transduction domain (PTD) to inhibit the c-Jun NH2-terminal kinase (JNK) pathway thereby attenuating ischemia-reperfusion injury in a porcine model. The PTD-JNK inhibitor (JNKI) was administered into the renal artery, allowing it to be taken into various elements including vascular endothelial cells by endocytosis via the PTD. Serum creatinine and blood urea nitrogen concentrations were lower among PTD-JNKI than controls. In addition, renal tissue blood flow was maintained in the PTD-JNKI group, resulting in less tissue injury and fewer apoptotic cells. These results suggested that the PTD technique improved renal transplantation outcomes.

本文言語英語
ページ(範囲)2469-2475
ページ数7
ジャーナルTransplantation Proceedings
45
6
DOI
出版ステータス出版済み - 7 2013

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

フィンガープリント 「Effect of cell permeable peptide of c-Jun NH<sub>2</sub>-terminal kinase inhibitor on the attenuation of renal ischemia-reperfusion injury in pigs」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル