Effect of chronic inhibition of angiotensin converting enzyme on baroreceptor reflex in essential hypertension

H. Muratani, Y. Kimura, Kiyoshi Matsumura, Y. Noda, T. Eto, K. Fukiyama

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

We examined baroreflex function and plasma angiotensin II (Ang II) before and after the treatment with an angiotensin converting enzyme inhibitor (ACEI) in eight inpatients with essential hypertension (EHT). Baroreflex sensitivity (BS), expressed as a slope of linear relationship between %changes in mean blood pressure (BP) and those in plasma concentration of norepinephrine (pNE), was greater during BP reduction by sodium nitroprusside (SNP) than during BP elevation by phenylephrine (PE). Enalapril treatment for 7 days reduced BP without a significant change in heart rate and pNE. It also increased the BS in two cases during SNP infusion and in four cases during PE infusion. Ang II was not significantly reduced after enalapril, while plasma ACE activity was suppressed by about 80 % and plasma renin activity (PRA) was elevated. The changes in BS did not correlate with the changes in Ang II. The shift of barofunction curve with an enhancement of BS by enalapril therapy might not be attributed solely to the interaction between circulating Ang II and central baroreflex mechanisms.

元の言語英語
ページ(範囲)391-398
ページ数8
ジャーナルClinical and Experimental Hypertension
A10
発行部数S1
DOI
出版物ステータス出版済み - 1 1 1988

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Baroreflex
Peptidyl-Dipeptidase A
Angiotensin II
Enalapril
Blood Pressure
Nitroprusside
Phenylephrine
Norepinephrine
Angiotensin-Converting Enzyme Inhibitors
Renin
Essential Hypertension
Inhibition (Psychology)
Inpatients
Therapeutics
Heart Rate

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

これを引用

Effect of chronic inhibition of angiotensin converting enzyme on baroreceptor reflex in essential hypertension. / Muratani, H.; Kimura, Y.; Matsumura, Kiyoshi; Noda, Y.; Eto, T.; Fukiyama, K.

:: Clinical and Experimental Hypertension, 巻 A10, 番号 S1, 01.01.1988, p. 391-398.

研究成果: ジャーナルへの寄稿記事

Muratani, H. ; Kimura, Y. ; Matsumura, Kiyoshi ; Noda, Y. ; Eto, T. ; Fukiyama, K. / Effect of chronic inhibition of angiotensin converting enzyme on baroreceptor reflex in essential hypertension. :: Clinical and Experimental Hypertension. 1988 ; 巻 A10, 番号 S1. pp. 391-398.
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abstract = "We examined baroreflex function and plasma angiotensin II (Ang II) before and after the treatment with an angiotensin converting enzyme inhibitor (ACEI) in eight inpatients with essential hypertension (EHT). Baroreflex sensitivity (BS), expressed as a slope of linear relationship between {\%}changes in mean blood pressure (BP) and those in plasma concentration of norepinephrine (pNE), was greater during BP reduction by sodium nitroprusside (SNP) than during BP elevation by phenylephrine (PE). Enalapril treatment for 7 days reduced BP without a significant change in heart rate and pNE. It also increased the BS in two cases during SNP infusion and in four cases during PE infusion. Ang II was not significantly reduced after enalapril, while plasma ACE activity was suppressed by about 80 {\%} and plasma renin activity (PRA) was elevated. The changes in BS did not correlate with the changes in Ang II. The shift of barofunction curve with an enhancement of BS by enalapril therapy might not be attributed solely to the interaction between circulating Ang II and central baroreflex mechanisms.",
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