抄録
We recently reported that when an acidic calcium phosphate solution is mixed with β-tricalcium phosphate (β-TCP) granules, the resulting dicalcium phosphate dihydrate (DCPD) crystals form bridges between the β-TCP granules, creating a set interconnected porous structure in approximately 1 min. Although this self-setting β-TCP granular cement (β-TCPGC) is useful for clinical applications, the short setting time is a key drawback for handling. In this study, the setting time of β-TCPGC was adjusted with the addition of citric acid, which is a known inhibiter of DCPD crystal growth. As the concentration of citric acid in the acidic calcium phosphate solution increased, the amount of DCPD formation in the set β-TCPGC decreased, and the crystal morphology of DCPD became elongated. β-TCPGC prepared with various citric acid concentrations were used as grafting material in rat calvarial bone defects to evaluate bone regeneration in vivo. Four weeks after implantation, no inflammatory reaction and approximately 20% new bone formation were observed, regardless of the presence or absence of citric acid in the liquid phase of β-TCPGC. We concluded, therefore, that citric acid might be a useful retarder of β-TCPGC setting times.
| 元の言語 | 英語 |
|---|---|
| 記事番号 | 015027 |
| ジャーナル | Biomedical Materials (Bristol) |
| 巻 | 12 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 2 1 2017 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Biomaterials
- Biomedical Engineering
これを引用
Effect of citric acid on setting reaction and tissue response to β-TCP granular cement. / Fukuda, Naoyuki; Tsuru, Kanji; Mori, Yoshihide; Ishikawa, Kunio.
：: Biomedical Materials (Bristol), 巻 12, 番号 1, 015027, 01.02.2017.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Effect of citric acid on setting reaction and tissue response to β-TCP granular cement
AU - Fukuda, Naoyuki
AU - Tsuru, Kanji
AU - Mori, Yoshihide
AU - Ishikawa, Kunio
PY - 2017/2/1
Y1 - 2017/2/1
N2 - We recently reported that when an acidic calcium phosphate solution is mixed with β-tricalcium phosphate (β-TCP) granules, the resulting dicalcium phosphate dihydrate (DCPD) crystals form bridges between the β-TCP granules, creating a set interconnected porous structure in approximately 1 min. Although this self-setting β-TCP granular cement (β-TCPGC) is useful for clinical applications, the short setting time is a key drawback for handling. In this study, the setting time of β-TCPGC was adjusted with the addition of citric acid, which is a known inhibiter of DCPD crystal growth. As the concentration of citric acid in the acidic calcium phosphate solution increased, the amount of DCPD formation in the set β-TCPGC decreased, and the crystal morphology of DCPD became elongated. β-TCPGC prepared with various citric acid concentrations were used as grafting material in rat calvarial bone defects to evaluate bone regeneration in vivo. Four weeks after implantation, no inflammatory reaction and approximately 20% new bone formation were observed, regardless of the presence or absence of citric acid in the liquid phase of β-TCPGC. We concluded, therefore, that citric acid might be a useful retarder of β-TCPGC setting times.
AB - We recently reported that when an acidic calcium phosphate solution is mixed with β-tricalcium phosphate (β-TCP) granules, the resulting dicalcium phosphate dihydrate (DCPD) crystals form bridges between the β-TCP granules, creating a set interconnected porous structure in approximately 1 min. Although this self-setting β-TCP granular cement (β-TCPGC) is useful for clinical applications, the short setting time is a key drawback for handling. In this study, the setting time of β-TCPGC was adjusted with the addition of citric acid, which is a known inhibiter of DCPD crystal growth. As the concentration of citric acid in the acidic calcium phosphate solution increased, the amount of DCPD formation in the set β-TCPGC decreased, and the crystal morphology of DCPD became elongated. β-TCPGC prepared with various citric acid concentrations were used as grafting material in rat calvarial bone defects to evaluate bone regeneration in vivo. Four weeks after implantation, no inflammatory reaction and approximately 20% new bone formation were observed, regardless of the presence or absence of citric acid in the liquid phase of β-TCPGC. We concluded, therefore, that citric acid might be a useful retarder of β-TCPGC setting times.
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UR - http://www.scopus.com/inward/citedby.url?scp=85015987932&partnerID=8YFLogxK
U2 - 10.1088/1748-605X/aa5aea
DO - 10.1088/1748-605X/aa5aea
M3 - Article
C2 - 28233758
AN - SCOPUS:85015987932
VL - 12
JO - Biomedical Materials (Bristol)
JF - Biomedical Materials (Bristol)
SN - 1748-6041
IS - 1
M1 - 015027
ER -