Effect of dietary fats and sesamin on the lipid metabolism and immune function of sprague-dawley rats

Jiongyan Gu, Yoko Wakizono, Aika Dohi, Michiko Nonaka, Michihiro Sugano

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抄録

We examined the effect of three dietary fats, safflower oil (SAF) rich in linoleic acid, borage oil (BOR) rich in γ-linolenic acid, and perilla oil (PER) rich in α-linolenic acid, on the lipid metabolism, and chemical mediator and immunoglobulin levels in Sprague-Dawley rats, as well as the dietary effect of sesame-derived antioxidative sesamin. The serum cholesterol, phospholipid, triglyceride, prostaglandin E2 level and splenic leukotriene B4 level were lower in the rats fed on BOR or PER than in those fed on SAF. SES feeding suppressed the expression of the lipid-decreasing effect of BOR, but not in the rats fed on PER. In respect of the fatty acid composition of the liver and spleen, PER feeding gave a lower arachidonic acid level, and higher eicosapentaenoic and docosahexaenoic acid levels than SAF feeding did, while the effect of BOR feeding was marginal. The effect of SES feeding on fatty acid composition was much smaller than that of dietary fats. In respect of immunoglobulin production, PER+SES feeding gave the lowest IgE productivity in the mesenteric lymph node lymphocytes. These results suggest that PER feeding regulated lipid metabolism and exerted an anti-allergic effect by a different mechanism from that with BOR feeding.

元の言語英語
ページ(範囲)1917-1924
ページ数8
ジャーナルBioscience, Biotechnology and Biochemistry
62
発行部数10
DOI
出版物ステータス出版済み - 1 1 1998

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Dietary Fats
Lipid Metabolism
Sprague Dawley Rats
Rats
Safflower Oil
alpha-Linolenic Acid
Immunoglobulins
Fatty Acids
Sesamum
Anti-Allergic Agents
Leukotriene B4
Eicosapentaenoic Acid
Docosahexaenoic Acids
Linoleic Acid
Dinoprostone
Arachidonic Acid
Immunoglobulin E
Lymphocytes
perilla seed oil
sesamin

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

これを引用

Effect of dietary fats and sesamin on the lipid metabolism and immune function of sprague-dawley rats. / Gu, Jiongyan; Wakizono, Yoko; Dohi, Aika; Nonaka, Michiko; Sugano, Michihiro.

:: Bioscience, Biotechnology and Biochemistry, 巻 62, 番号 10, 01.01.1998, p. 1917-1924.

研究成果: ジャーナルへの寄稿記事

Gu, Jiongyan ; Wakizono, Yoko ; Dohi, Aika ; Nonaka, Michiko ; Sugano, Michihiro. / Effect of dietary fats and sesamin on the lipid metabolism and immune function of sprague-dawley rats. :: Bioscience, Biotechnology and Biochemistry. 1998 ; 巻 62, 番号 10. pp. 1917-1924.
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