Effect of DNA methylation on the velocity of DNA translocation through a nanochannel

Xiaoyin Sun, Takao Yasui, Takeshi Yanagida, Noritada Kaji, Sakon Rahong, Masaki Kanai, Kazuki Nagashima, Tomoji Kawai, Yoshinobu Baba

研究成果: ジャーナルへの寄稿記事

抜粋

Here, we report the effect of DNA methylation on the velocity of DNA translocation through a nanochannel, as determined by measuring differences in translocation velocities between methylated and non-methylated DNA molecules. We found that the velocity of translocation of methylated DNA was faster than that of non-methylated DNA, which we attributed to variation in the coefficients of diffusion and friction with the nanochannel wall, due to the increased molecular weight and stiffness, respectively, of methylated DNA.

元の言語英語
ページ(範囲)727-730
ページ数4
ジャーナルanalytical sciences
33
発行部数6
DOI
出版物ステータス出版済み - 1 1 2017

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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