TY - JOUR
T1 - Effect of Dosing Time on Trazodone Kinetics
AU - Nakano, Shigeyuki
AU - Ogawa, Nobuya
AU - Watanabe, Kouki
AU - Naruo, Tetsuro
AU - Takaoka, Nobuyuki
AU - Ohdo, Shigehiro
AU - Arai, Tatsuru
PY - 1992
Y1 - 1992
N2 - Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50 mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher Cmax and significantly larger AUCo-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.
AB - Effects of dosing time of trazodone hydrochloride, (KB-831), a new antidepressant drug, on the pharmacokinetics were investigated by a cross-over method using 6 healthy male volunteers administered 50 mg of the drug orally after breakfast or after supper. There were some effects of dosing time on the pharmacokinetics of trazodone hydrochloride, showing significantly higher Cmax and significantly larger AUCo-24hr in the group administered in the morning than in the evening. Mild drowsiness, dizziness, and dry mouth observed after the administration of trazodone hydrochloride were relatively stronger in the group administered in the morning than in the evening. From these results, it could be presumed that a single oral administration of the drug before sleep might be better for the reduction of the side effects of the drug.
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U2 - 10.3999/jscpt.23.445
DO - 10.3999/jscpt.23.445
M3 - Article
AN - SCOPUS:0026645751
VL - 23
SP - 445
EP - 451
JO - Japanese Journal of Clinical Pharmacology and Therapeutics
JF - Japanese Journal of Clinical Pharmacology and Therapeutics
SN - 0388-1601
IS - 2
ER -