Effect of drug-metabolizing enzyme activity induced by PCB on the duration of drugs in fish

Y. Oshima, K. Kobayashi, J. F. Lumbanbatu, K. Ooie, Y. Kawahara, N. Imada

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

A study was made of the induction of drug-metabolizing enzyme activity and the effect of the induced activity on the duration of drugs in fish. Carp were fed with a diet containing PCB ( 0.1 mg PCB 100 g body weight day-1) for 2 weeks to induce drug-metabolizing enzymes. After pretreatment, oxolinic acid, thiamphenicol and oxytetracycline were administered in feed to PCB-treated and nontreated (as control) fish as a single dose of 20, 50, and 50 mg/kg body weight, respectively. The peak concentrations of oxolinic acid in the blood, kidney, liver, and muscle of fish in the PCB group were lower than the half of those in the controls. Furthermore, the duration times of oxolinic acid in the tissues of PCB-treated fish were also shorter than those in the control. However, the duration of thiamphenicol and oxytetracycline showed no significant changes relating to PCB treatment.

元の言語英語
ページ(範囲)25-31
ページ数7
ジャーナルAquaculture
120
発行部数1-2
DOI
出版物ステータス出版済み - 2 15 1994

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oxolinic acid
enzyme activity
PCB
drug
thiamphenicol
drugs
duration
oxytetracycline
fish
body weight
acid
carp
pretreatment
kidneys
muscles
liver
effect
blood
muscle
dosage

All Science Journal Classification (ASJC) codes

  • Aquatic Science

これを引用

Effect of drug-metabolizing enzyme activity induced by PCB on the duration of drugs in fish. / Oshima, Y.; Kobayashi, K.; Lumbanbatu, J. F.; Ooie, K.; Kawahara, Y.; Imada, N.

:: Aquaculture, 巻 120, 番号 1-2, 15.02.1994, p. 25-31.

研究成果: ジャーナルへの寄稿記事

Oshima, Y, Kobayashi, K, Lumbanbatu, JF, Ooie, K, Kawahara, Y & Imada, N 1994, 'Effect of drug-metabolizing enzyme activity induced by PCB on the duration of drugs in fish', Aquaculture, 巻. 120, 番号 1-2, pp. 25-31. https://doi.org/10.1016/0044-8486(94)90218-6
Oshima, Y. ; Kobayashi, K. ; Lumbanbatu, J. F. ; Ooie, K. ; Kawahara, Y. ; Imada, N. / Effect of drug-metabolizing enzyme activity induced by PCB on the duration of drugs in fish. :: Aquaculture. 1994 ; 巻 120, 番号 1-2. pp. 25-31.
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abstract = "A study was made of the induction of drug-metabolizing enzyme activity and the effect of the induced activity on the duration of drugs in fish. Carp were fed with a diet containing PCB ( 0.1 mg PCB 100 g body weight day-1) for 2 weeks to induce drug-metabolizing enzymes. After pretreatment, oxolinic acid, thiamphenicol and oxytetracycline were administered in feed to PCB-treated and nontreated (as control) fish as a single dose of 20, 50, and 50 mg/kg body weight, respectively. The peak concentrations of oxolinic acid in the blood, kidney, liver, and muscle of fish in the PCB group were lower than the half of those in the controls. Furthermore, the duration times of oxolinic acid in the tissues of PCB-treated fish were also shorter than those in the control. However, the duration of thiamphenicol and oxytetracycline showed no significant changes relating to PCB treatment.",
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AU - Kawahara, Y.

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N2 - A study was made of the induction of drug-metabolizing enzyme activity and the effect of the induced activity on the duration of drugs in fish. Carp were fed with a diet containing PCB ( 0.1 mg PCB 100 g body weight day-1) for 2 weeks to induce drug-metabolizing enzymes. After pretreatment, oxolinic acid, thiamphenicol and oxytetracycline were administered in feed to PCB-treated and nontreated (as control) fish as a single dose of 20, 50, and 50 mg/kg body weight, respectively. The peak concentrations of oxolinic acid in the blood, kidney, liver, and muscle of fish in the PCB group were lower than the half of those in the controls. Furthermore, the duration times of oxolinic acid in the tissues of PCB-treated fish were also shorter than those in the control. However, the duration of thiamphenicol and oxytetracycline showed no significant changes relating to PCB treatment.

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