Effect of epivascular cardiac autonomic nerve stimulation on cardiac function

Mariko Kobayashi, Seiichiro Sakurai, Tohru Takaseya, Akira Shiose, Hyun Il Kim, Masako Fujiki, Jamshid H. Karimov, Raymond Dessoffy, Alex Massiello, Allen G. Borowski, David R. Van Wagoner, Eugene J. Jung, Kiyotaka Fukamachi

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Background: The cardiac plexus contains sympathetic and parasympathetic cardiac nerves. Our goal was to assess the hemodynamic and functional effects of stimulating the cardiac autonomic nervous system (CANS) at the epivascular surfaces of the cardiac plexus. Although CANS therapy to modulate cardiovascular function has drawn widespread interest, research has focused only on stimulating parasympathetic or sympathetic nerves, not both at once. Methods: Using general anesthesia and an open-chest surgical procedure, 12 dogs received epivascular stimulation of the cardiac plexus. A bipolar electrode was placed between the right pulmonary artery (PA) and the ascending aorta, with the stimulation frequency/pulse width held constant (20 Hz/4 ms) and the voltage varied (10-50 V). Left ventricular (LV) pressure-volume loops and hemodynamic data were recorded with and without stimulation. Results: In all dogs, aortic and LV systolic pressures, maximum rate of change of LV pressure, and LV stroke work increased (p < 0.0001), as did cardiac output (2.9 ± 1.0-0.4 ± 1.0 L/min; p = 0.001), end-systolic elastance (1.2 ± 0.4-1.5 ± 0.5 mm Hg/mL; p = 0.0001), preload recruitable stroke work (30.1 ± 11.0-39.3 ± 7.8 mm Hg; p = 0.003), and LV ejection fraction (p = 0.012). Systemic vascular resistance increased slightly (p = 0.04), and pulmonary vascular resistance decreased (p = 0.01). Mean heart rate and pulmonary arterial, central venous, and left atrial pressures remained unchanged (p > 0.1). Conclusions: In contrast to inotropic drugs, epivascular CANS stimulation induced a significant and selective increase in LV contractility with no increase in heart rate.

元の言語英語
ページ(範囲)1150-1156
ページ数7
ジャーナルAnnals of Thoracic Surgery
94
発行部数4
DOI
出版物ステータス出版済み - 10 1 2012

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Autonomic Pathways
Autonomic Nervous System
Ventricular Pressure
Hemodynamics
Dogs
General Anesthesia
Pulmonary Artery
Pulse
Aorta
Electrodes
Thorax
Heart Rate
Stroke
Blood Pressure
Research
Pharmaceutical Preparations
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

これを引用

Kobayashi, M., Sakurai, S., Takaseya, T., Shiose, A., Kim, H. I., Fujiki, M., ... Fukamachi, K. (2012). Effect of epivascular cardiac autonomic nerve stimulation on cardiac function. Annals of Thoracic Surgery, 94(4), 1150-1156. https://doi.org/10.1016/j.athoracsur.2012.04.092

Effect of epivascular cardiac autonomic nerve stimulation on cardiac function. / Kobayashi, Mariko; Sakurai, Seiichiro; Takaseya, Tohru; Shiose, Akira; Kim, Hyun Il; Fujiki, Masako; Karimov, Jamshid H.; Dessoffy, Raymond; Massiello, Alex; Borowski, Allen G.; Van Wagoner, David R.; Jung, Eugene J.; Fukamachi, Kiyotaka.

:: Annals of Thoracic Surgery, 巻 94, 番号 4, 01.10.2012, p. 1150-1156.

研究成果: ジャーナルへの寄稿記事

Kobayashi, M, Sakurai, S, Takaseya, T, Shiose, A, Kim, HI, Fujiki, M, Karimov, JH, Dessoffy, R, Massiello, A, Borowski, AG, Van Wagoner, DR, Jung, EJ & Fukamachi, K 2012, 'Effect of epivascular cardiac autonomic nerve stimulation on cardiac function', Annals of Thoracic Surgery, 巻. 94, 番号 4, pp. 1150-1156. https://doi.org/10.1016/j.athoracsur.2012.04.092
Kobayashi, Mariko ; Sakurai, Seiichiro ; Takaseya, Tohru ; Shiose, Akira ; Kim, Hyun Il ; Fujiki, Masako ; Karimov, Jamshid H. ; Dessoffy, Raymond ; Massiello, Alex ; Borowski, Allen G. ; Van Wagoner, David R. ; Jung, Eugene J. ; Fukamachi, Kiyotaka. / Effect of epivascular cardiac autonomic nerve stimulation on cardiac function. :: Annals of Thoracic Surgery. 2012 ; 巻 94, 番号 4. pp. 1150-1156.
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abstract = "Background: The cardiac plexus contains sympathetic and parasympathetic cardiac nerves. Our goal was to assess the hemodynamic and functional effects of stimulating the cardiac autonomic nervous system (CANS) at the epivascular surfaces of the cardiac plexus. Although CANS therapy to modulate cardiovascular function has drawn widespread interest, research has focused only on stimulating parasympathetic or sympathetic nerves, not both at once. Methods: Using general anesthesia and an open-chest surgical procedure, 12 dogs received epivascular stimulation of the cardiac plexus. A bipolar electrode was placed between the right pulmonary artery (PA) and the ascending aorta, with the stimulation frequency/pulse width held constant (20 Hz/4 ms) and the voltage varied (10-50 V). Left ventricular (LV) pressure-volume loops and hemodynamic data were recorded with and without stimulation. Results: In all dogs, aortic and LV systolic pressures, maximum rate of change of LV pressure, and LV stroke work increased (p < 0.0001), as did cardiac output (2.9 ± 1.0-0.4 ± 1.0 L/min; p = 0.001), end-systolic elastance (1.2 ± 0.4-1.5 ± 0.5 mm Hg/mL; p = 0.0001), preload recruitable stroke work (30.1 ± 11.0-39.3 ± 7.8 mm Hg; p = 0.003), and LV ejection fraction (p = 0.012). Systemic vascular resistance increased slightly (p = 0.04), and pulmonary vascular resistance decreased (p = 0.01). Mean heart rate and pulmonary arterial, central venous, and left atrial pressures remained unchanged (p > 0.1). Conclusions: In contrast to inotropic drugs, epivascular CANS stimulation induced a significant and selective increase in LV contractility with no increase in heart rate.",
author = "Mariko Kobayashi and Seiichiro Sakurai and Tohru Takaseya and Akira Shiose and Kim, {Hyun Il} and Masako Fujiki and Karimov, {Jamshid H.} and Raymond Dessoffy and Alex Massiello and Borowski, {Allen G.} and {Van Wagoner}, {David R.} and Jung, {Eugene J.} and Kiyotaka Fukamachi",
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AU - Kobayashi, Mariko

AU - Sakurai, Seiichiro

AU - Takaseya, Tohru

AU - Shiose, Akira

AU - Kim, Hyun Il

AU - Fujiki, Masako

AU - Karimov, Jamshid H.

AU - Dessoffy, Raymond

AU - Massiello, Alex

AU - Borowski, Allen G.

AU - Van Wagoner, David R.

AU - Jung, Eugene J.

AU - Fukamachi, Kiyotaka

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