Effect of extended colostrum feeding on plasma glucagon-like peptide-1 concentration in newborn calves

Y. Inabu, J. Pyo, S. Pletts, L. L. Guan, M. A. Steele, T. Sugino

研究成果: Contribution to journalArticle査読

11 被引用数 (Scopus)

抄録

Glucagon-like peptide-1 (GLP-1) plays a role in the regulation of glucose homeostasis via the stimulation of insulin secretion. The objective of this study was to evaluate the effect of extended colostrum feeding on plasma concentration of GLP-1. Holstein bull calves (n = 27) were fed pooled colostrum at 7.5% of birth body weight at 2 h after birth and then fed mature milk (M), a 50:50 mixture of pooled colostrum and milk (CM), or pooled colostrum (C; n = 9 for each treatment) at 5% of birth body weight at 12 h after birth and every 12 h thereafter until 72 h after birth. Blood samples were obtained before (1 and 2 h after birth) and after (until 72 h after birth; 42 time points) the first colostrum feeding, and plasma concentrations of glucose, insulin, and GLP-1 were measured. Data were analyzed by ANOVA of JMP 13 (SAS Institute Inc., Cary, NC) with treatment, time, and treatment × time interaction as fixed effects. Treatment × time interaction was observed for plasma insulin and glucose concentrations, which were mainly the result of lower concentrations from 1 to 2 d after birth for C compared with M. Conversely, on d 3 after birth, the difference between treatments was not observed for insulin and glucose. For the entire experimental period, plasma GLP-1 concentration was higher for C (2.25 ng/mL) compared with M (1.41 ng/mL) and tended to be higher compared with CM (1.58 ng/mL). A treatment × time interaction was observed for GLP-1, but unlike glucose and insulin, this was mainly the result of higher concentrations from 54 to 72 h after birth (on d 3 after birth) for C compared with M or CM. Postprandial plasma concentration of glucose was not correlated with that of GLP-1 but was positively correlated with that of insulin for the 4-h period after feeding on d 1 (r = 0.30) and d 3 after birth (r = 0.33). Postprandial plasma concentration of GLP-1 was positively correlated with that of insulin for the 4-h period after feeding on d 3 after birth (r = 0.20). These results indicate that extended colostrum feeding may increase plasma GLP-1 concentrations, especially 3 d after birth, but further study is necessary to determine the effect on plasma insulin and glucose concentrations.

本文言語英語
ページ(範囲)4619-4627
ページ数9
ジャーナルJournal of Dairy Science
102
5
DOI
出版ステータス出版済み - 5 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 食品科学
  • 動物科学および動物学
  • 遺伝学

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