Effect of glucocorticoid replacement on tumor growth after adrenalectomy in mice

Yoshihiko Maehara, Yoichiro Hiramoto, Kouhei Akazawa, Yoshihisa Sakaguchi, Ryuichiro Tamada, Keizo Sugimachi

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

We studied the effects of glucocorticoid replacement on tumor growth after adrenalectomy of Meth A sarcoma in mice. Tumor growth was inhibited in the adrenalectomized mice when a minimum dose of corticosterone, 0.3 mg/day, was given for replacement, and higher doses led to an even greater inhibition. Corticosterone had no effect on tumor growth in the irradiated mice. Sinecomitant immunity in the case of growth of the retransplanted excised tumor was compromised in the adrenalectomized mice. In vivo neutralization and immunosuppressive activities were absent in the spleen cells of the adrenalectomized mice. It would thus appear that adrenalectomy suppresses tumor growth by mechanisms other than glucocorticoid ablation. For optimum tumor control, glucocorticoid replacement after adrenalectomy should be in excess of the minimum daily requirements.

本文言語英語
ページ(範囲)2048-2051
ページ数4
ジャーナルCancer Research
49
8
出版ステータス出版済み - 4 1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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