TY - JOUR
T1 - Effect of gut microbiota early in life on aggressive behavior in mice
AU - Watanabe, Natsuru
AU - Mikami, Katsunaka
AU - Hata, Tomokazu
AU - Kimoto, Keitaro
AU - Nishino, Ryo
AU - Akama, Fumiaki
AU - Yamamoto, Kenji
AU - Sudo, Nobuyuki
AU - Koga, Yasuhiro
AU - Matsumoto, Hideo
N1 - Funding Information:
Fumiaki Akama has received research support from Otsuka Pharmaceutical and Shionogi & Co.; and honoraria from Dainippon Sumitomo Pharma, Pfizer, Shionogi & Co. and Eisai Co.
Funding Information:
KenjiYamamoto reports receiving grants and personal fees from Eisai Co., Ltd., Japan; grants and personal fees from Otsuka Pharmaceutical Co., Ltd., Japan; personal fees from Meiji Seika Pharma Co., Ltd.; personal fees from Sumitomo Dainippon Pharma Co., Ltd.; personal fees from Pfizer Japan Inc.; personal fees from Mitsubishi Tanabe Pharma Corporation; personal fees from Shionogi & Co.; personal fees from Eli Lilly and Company; personal fees from EPS Holdings, Inc.; grants from Grant-in-Aid for Scientific Research (16K10260) outside the submitted work.
Funding Information:
Tomokazu Hata received research support from Foundation of Kinoshita Memorial Enterprise.
Publisher Copyright:
© 2021 Elsevier B.V. and Japan Neuroscience Society
PY - 2021/7
Y1 - 2021/7
N2 - Recent reports have indicated that gut microbiota modulates the responses to stress through the microbiota-gut-brain axis in mice, suggesting a connection between gut microbiota and brain function. We hypothesized that the gut microbiota early in life would have an effect on aggressiveness, and examined how gut microbiota affect aggressive behaviors in mice. BALB/c mice were housed in germ-free (GF) and ex-germ-free (Ex-GF) isolators. An aggression test was performed between castrated and a non-castrated mice at 8 weeks of age; the mice were allowed to confront each other for 10 min in strictly contamination-free environments. To evaluate aggressive behavior related to gut microbiota, we orally administered diluted Ex-GF mouse feces to the offspring of GF mice at 0, 6, and 10 weeks. GF mice showed more aggression than Ex-GF mice. Furthermore, GF mice who were administered feces of the Ex-GF group at 0-week-old were less aggressive than the GF mice. These findings suggested that the gut microbiota in the early stages of development was likely to have an effect on aggressiveness. Maintenance of healthy gut microbiota early in life can affect the mitigation of aggressive behavioral characteristics throughout the lifetime.
AB - Recent reports have indicated that gut microbiota modulates the responses to stress through the microbiota-gut-brain axis in mice, suggesting a connection between gut microbiota and brain function. We hypothesized that the gut microbiota early in life would have an effect on aggressiveness, and examined how gut microbiota affect aggressive behaviors in mice. BALB/c mice were housed in germ-free (GF) and ex-germ-free (Ex-GF) isolators. An aggression test was performed between castrated and a non-castrated mice at 8 weeks of age; the mice were allowed to confront each other for 10 min in strictly contamination-free environments. To evaluate aggressive behavior related to gut microbiota, we orally administered diluted Ex-GF mouse feces to the offspring of GF mice at 0, 6, and 10 weeks. GF mice showed more aggression than Ex-GF mice. Furthermore, GF mice who were administered feces of the Ex-GF group at 0-week-old were less aggressive than the GF mice. These findings suggested that the gut microbiota in the early stages of development was likely to have an effect on aggressiveness. Maintenance of healthy gut microbiota early in life can affect the mitigation of aggressive behavioral characteristics throughout the lifetime.
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U2 - 10.1016/j.neures.2021.01.005
DO - 10.1016/j.neures.2021.01.005
M3 - Article
C2 - 33476684
AN - SCOPUS:85100620913
VL - 168
SP - 95
EP - 99
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
ER -