Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes

Takashi Hasegawa, Yuki Kimura, Kenji Hiromatsu, Noritada Kobayashi, Akira Yamada, Masahiko Makino, Masao Okuda, Toshihiko Sano, Kikuo Nomoto, Yasunobu Yoshikai

    研究成果: ジャーナルへの寄稿学術誌査読

    71 被引用数 (Scopus)

    抄録

    We have previously reported that oral administration of hot water extract of Chlorella vulgaris (CVE) enhances resistance to Listeria monocytogenes through augmentation of Listeria-specific cell-mediated immunity in normal mice and mice with murine acquired immunodeficiency syndrome (MAIDS) caused by murine leukemia virus (MuLV) LP-BM5. To elucidate the mechanisms whereby CVE augments the cell-mediated immunity, we examined the expression patterns of mRNA for cytokines in normal and MAIDS mice given CVE orally after L. monocytogenes infection. The expression levels of IL-1α, IL-12, GM-CSF, MIP and TNFα genes were significantly augmented in the peritoneal adherent cells by oral administration of CVE for 2 weeks before Listeria infection. The expression levels of γIFN and IL-12 mRNA were significantly higher in the spleen after Listeria infection in CVE-treated mice than in normal mice, while the expression of IL-10 mRNA in the spleen was decreased by CVE administration. In MAIDS mice, oral administration of CVE also augmented the expression of γIFN and IL-12 mRNA in the spleen after Listeria infection, while it rather reduced the expression of IL-10 mRNA. These results suggest that CVE may preferentially augment Th1 responses against Listeria via activation of macrophages to produce IL-12 and enhance host defense against Listeria infection both in normal and MAIDS mice.

    本文言語英語
    ページ(範囲)273-282
    ページ数10
    ジャーナルImmunopharmacology
    35
    3
    DOI
    出版ステータス出版済み - 1月 1997

    !!!All Science Journal Classification (ASJC) codes

    • 薬理学

    フィンガープリント

    「Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodeficiency syndrome after infection with Listeria monocytogenes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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