Effect of hydrophilic soft segment side chains on the surface properties and blood compatibility of segmented poly (urethaneureas)

Atsushi Takahara, Ann Z. Okkema, Hugh Wabers, Stuart L. Cooper

研究成果: Contribution to journalArticle査読

42 被引用数 (Scopus)

抄録

Segmented poly(urethaneureas) with hydrophilic side chains were prepared from poly(tetramethylene oxide) (PTMO), 4,4′‐diphenylmethane diisocyanate (MDI), ethylene diamine (ED) and a diol with a long hydrophilic side chain comprised of an ethylene oxide‐propylene oxide copolymer. The end groups of the hydrophilic chains were either sodium sulfonate or methoxy groups. The state of microphase separation showed a small dependece on the fraction of long‐chain hydrophilic diol. Surface analysis by means of static underwater contact angle and dynamic contact angle measurements revealed that the graft chains were at the aqueous interface in the hydrated state. An ex vivo A‐V shunt experiment revealed that a more thrombogenic blood‐material response was correlated with an increase in the concentration of polymeric hydrophilic side chain incorporation. The polyurethane containing a long chain diol with methoxy end groups exhibited a higher level of thrombogenicity than the similar polymers possessing a sulfonate terminated side chain.

本文言語英語
ページ(範囲)1095-1118
ページ数24
ジャーナルJournal of Biomedical Materials Research
25
9
DOI
出版ステータス出版済み - 9 1991

All Science Journal Classification (ASJC) codes

  • 生体材料
  • 生体医工学

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