Effect of IL-10 on collagen-induced arthritis in mice

Y. Tanaka, T. Otsuka, T. Hotokebuchi, H. Miyahara, H. Nakashima, S. Kuga, Y. Nemoto, H. Niiro, Y. Niho

研究成果: ジャーナルへの寄稿記事

76 引用 (Scopus)

抄録

In the present study we investigated the effect of a potent anti-inflammatory cytokine, interleukin (IL)-10, on the development of collagen-induced arthritis (CIA) in mice. Each DBA1/J mouse was immunized with 200 μg of native collagen and followed by booster injections at 3 weeks. rmIL-10 was injected i.p. daily at a dose of 100 ng/mouse. Mice were divided into four groups according to the administration period of rmIL-10. As a result, a 48-day course of IL-10 treatment significantly suppressed the severity of arthritis. Among the 4 groups, the most pronounced suppression was observed in the group in which IL-10 was given from day 0 to 21. On the other hand, there were no significant differences in the serum IgG anti-type II collagen (CII) titers between the four groups. Moreover, the production of cytokines (IL-6 and tumor necrosis factor-α (TNF-α)) and other mediators (prostaglandin E2 (PGE2) and nitric oxide (NO)) by peritoneal macrophages seemed to show no clear correlation with the severity of arthritis in mice. These results raise the possibility that IL-10 might be a useful agent for suppressing the progression and the development of CIA in mice.

元の言語英語
ページ(範囲)283-288
ページ数6
ジャーナルInflammation Research
45
発行部数6
DOI
出版物ステータス出版済み - 7 11 1996

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Experimental Arthritis
Interleukin-10
Arthritis
Cytokines
Collagen Type II
Peritoneal Macrophages
Dinoprostone
Interleukin-6
Nitric Oxide
Anti-Inflammatory Agents
Collagen
Tumor Necrosis Factor-alpha
Injections
Serum

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

これを引用

Tanaka, Y., Otsuka, T., Hotokebuchi, T., Miyahara, H., Nakashima, H., Kuga, S., ... Niho, Y. (1996). Effect of IL-10 on collagen-induced arthritis in mice. Inflammation Research, 45(6), 283-288. https://doi.org/10.1007/BF02280992

Effect of IL-10 on collagen-induced arthritis in mice. / Tanaka, Y.; Otsuka, T.; Hotokebuchi, T.; Miyahara, H.; Nakashima, H.; Kuga, S.; Nemoto, Y.; Niiro, H.; Niho, Y.

:: Inflammation Research, 巻 45, 番号 6, 11.07.1996, p. 283-288.

研究成果: ジャーナルへの寄稿記事

Tanaka, Y, Otsuka, T, Hotokebuchi, T, Miyahara, H, Nakashima, H, Kuga, S, Nemoto, Y, Niiro, H & Niho, Y 1996, 'Effect of IL-10 on collagen-induced arthritis in mice', Inflammation Research, 巻. 45, 番号 6, pp. 283-288. https://doi.org/10.1007/BF02280992
Tanaka Y, Otsuka T, Hotokebuchi T, Miyahara H, Nakashima H, Kuga S その他. Effect of IL-10 on collagen-induced arthritis in mice. Inflammation Research. 1996 7 11;45(6):283-288. https://doi.org/10.1007/BF02280992
Tanaka, Y. ; Otsuka, T. ; Hotokebuchi, T. ; Miyahara, H. ; Nakashima, H. ; Kuga, S. ; Nemoto, Y. ; Niiro, H. ; Niho, Y. / Effect of IL-10 on collagen-induced arthritis in mice. :: Inflammation Research. 1996 ; 巻 45, 番号 6. pp. 283-288.
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