Effect of intracerebroventricular injection of l-pipecolic acid on gab a concentrations in brain sites of neonatal chicks

T. Takagi, Y. H. Choi, T. Tachibana, D. M. Denbow, M. Furuse

研究成果: ジャーナルへの寄稿記事

抄録

L-pipecolic acid (L-PA) is a major metabolic intermediate of L-lysine in the mammalian and chicken brain, which enhances y-amino butyric acid (GABA) release and inhibits GABA re-uptake. Our previous study showed that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-like behavior in neonatal chicks. These behaviors which are associated with the GABA system, suggest a link between L-PA and GABA. The present study was designed to determine GABA concentrations in several chick brain sites after i.c.v. injection of L-PA. Unexpectedly, L-PA tended to decrease GABA concentrations in all brain sites tested except for the pons-medulla oblongata and the decrease was largest in the optic lobe. These results, taken together with previous findings, support a link between i.c.v. L-PA and extracellular GABA concentrations.

元の言語英語
ページ(範囲)9-13
ページ数5
ジャーナルJournal of Applied Animal Research
28
発行部数1
DOI
出版物ステータス出版済み - 1 1 2005

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pipecolic acid
gamma-aminobutyric acid
gamma-Aminobutyric Acid
chicks
injection
brain
Injections
Brain
medulla oblongata
optic lobe
Medulla Oblongata
Butyric Acid
Pons
butyric acid
sleep
Lysine
Chickens
lysine
Sleep
chickens

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

これを引用

Effect of intracerebroventricular injection of l-pipecolic acid on gab a concentrations in brain sites of neonatal chicks. / Takagi, T.; Choi, Y. H.; Tachibana, T.; Denbow, D. M.; Furuse, M.

:: Journal of Applied Animal Research, 巻 28, 番号 1, 01.01.2005, p. 9-13.

研究成果: ジャーナルへの寄稿記事

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AU - Denbow, D. M.

AU - Furuse, M.

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