We examined effects of intravenous administration of glucagon-like peptide 1 (GLP-1) on growth hormone (GH) secretion in ruminants. Four Suffolk rams, aged 2 years, were fed at 16.00 h. They were bled every 5 min from 12.00 until 17.00 h. GLP-1(7-36)amide was intravenously infused at a rate of 1.2 pmol/kg/min from 12.00 to 17.00 h. GH peak frequency was significantly (P<0.05) increased. GLP-1 did not affect GH peak amplitude. Plasma insulin levels transiently increased just after the start of GLP-1 infusion. Plasma glucose levels did not change. GLP-1 may be a physiological regulator of spontaneous pulsatile GH secretion in ruminants.
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