Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution

Yoichi Takakusagi, Kaori Inoue, Tatsuya Naganuma, Fuminori Hyodo, Kazuhiro Ichikawa

    研究成果: ジャーナルへの寄稿学術誌査読

    1 被引用数 (Scopus)

    抄録

    In hyperpolarization of 13C-enriched magnetic resonance chemical probes in the solid-state, a trace amount of gadolinium (Gd) contrast agent can be used to maximize polarization of the 13C nuclear spins. Here, we report systematic measurement of the spin-lattice relaxation time (T1) and enhancement level of 13C-enriched chemical probes in the presence of various Gd contrast agents in the liquid-state after dissolution. Using two different 13C probes having opposite electric charges at neutral pH, we clearly show the T1 of hyperpolarized 13C was barely affected by the use of a Gd complex that displays repulsive interaction with the 13C probe in solution, whilst T1 was drastically shortened when there was ionic attraction between probe and complex.

    本文言語英語
    ページ(範囲)157-160
    ページ数4
    ジャーナルJournal of Magnetic Resonance
    270
    DOI
    出版ステータス出版済み - 9月 1 2016

    !!!All Science Journal Classification (ASJC) codes

    • 生物理学
    • 生化学
    • 核物理学および高エネルギー物理学
    • 凝縮系物理学

    フィンガープリント

    「Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル