Effect of irreversible electroporation on three-dimensional cell culture model

Kosaku Kurata, Masahiro Matsushita, Takashi Yoshii, Takanobu Fukunaga, Hiroshi Takamatsu

研究成果: 著書/レポートタイプへの貢献会議での発言

3 引用 (Scopus)

抄録

Irreversible electroporation (IRE) is a new treatment to necrotize abnormal cells by high electric pulses. Electric potential difference over 1 V across the plasma membrane permanently permeabilizes the cell with keeping the extracellular matrix intact if the thermal damage due to the Joule heating effect is avoided. This is the largest advantage of the IRE compared to the other conventional treatment. However, since the IRE has just started to be used in clinical tests, it is important to predict the necrotized region that depends on pulse parameters and electrode arrangement. We therefore examined the numerical solution to the Laplace equation for the static electric field to predict the IRE-induced cell necrosis. Three-dimensionally (3-D) cultured cells in a tissue phantom were experimentally subjected to the electric pulses through a pair of puncture electrodes. The necrotized area was determined as a function of the pulse repetition and compared with the area that was estimated by the numerical analysis.

元の言語英語
ホスト出版物のタイトル2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
ページ179-182
ページ数4
DOI
出版物ステータス出版済み - 12 14 2012
イベント34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, 米国
継続期間: 8 28 20129 1 2012

出版物シリーズ

名前Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN(印刷物)1557-170X

その他

その他34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
米国
San Diego, CA
期間8/28/129/1/12

Fingerprint

Electroporation
Cell culture
Cell Culture Techniques
Electrodes
Joule heating
Laplace equation
Cell membranes
Numerical analysis
Cells
Electric fields
Tissue
Electric potential
Punctures
Heating
Extracellular Matrix
Cultured Cells
Necrosis
Hot Temperature
Cell Membrane
Therapeutics

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

これを引用

Kurata, K., Matsushita, M., Yoshii, T., Fukunaga, T., & Takamatsu, H. (2012). Effect of irreversible electroporation on three-dimensional cell culture model. : 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012 (pp. 179-182). [6345900] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6345900

Effect of irreversible electroporation on three-dimensional cell culture model. / Kurata, Kosaku; Matsushita, Masahiro; Yoshii, Takashi; Fukunaga, Takanobu; Takamatsu, Hiroshi.

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. p. 179-182 6345900 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

研究成果: 著書/レポートタイプへの貢献会議での発言

Kurata, K, Matsushita, M, Yoshii, T, Fukunaga, T & Takamatsu, H 2012, Effect of irreversible electroporation on three-dimensional cell culture model. : 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012., 6345900, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 179-182, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, San Diego, CA, 米国, 8/28/12. https://doi.org/10.1109/EMBC.2012.6345900
Kurata K, Matsushita M, Yoshii T, Fukunaga T, Takamatsu H. Effect of irreversible electroporation on three-dimensional cell culture model. : 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. p. 179-182. 6345900. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6345900
Kurata, Kosaku ; Matsushita, Masahiro ; Yoshii, Takashi ; Fukunaga, Takanobu ; Takamatsu, Hiroshi. / Effect of irreversible electroporation on three-dimensional cell culture model. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. pp. 179-182 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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