Effect of l-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans

Yoshitaka Hirooka, Kensuke Egashira, Tsutomu Imaizumi, Tatsuya Tagawa, Hisashi Kai, Masaru Sugimachi, Akira Takeshita

研究成果: ジャーナルへの寄稿学術誌査読

88 被引用数 (Scopus)

抄録

Objectives. The goal of this study was to determine whether the elect of l-arginine on endothelium-dependent vasoditation evoked with acetylcholine differs between the coronary and forearm vasculatures in humans. Background. Administration of l-arginine, a substrate in the production of endothetium-derived nitric oxide, may stimulate the release of nitric oxide. Methods. Seven patients with normal coronary angiograms and seven with mild coronary artery disease and hypertension underwent coronary arteriography and an intracoronary Doppler catheter technique, and the diameter of the large epicardial coronary artery and coronary blood flow were measured. Forearm blood flow was measured by use of a strain gauge plethysmograph. Results. Before l-arginine administration, acetylcholine (1 to 30 μg/min) increased coronary blood flow with modest vasoconstriction of a large coronary artery. Acetylcholine (4 to 24 μg/min) also increased forearm blood flow. The acetylcholine-induced increases in coronary and forearm blood flow were significantly less in patients with coronary artery disease than in control patients. Intracoronary infusion of l-arginine at 50 mg/min did not alter responses of the large coronary artery diameter or coronary blood flow to acetyicholine in either group. In contrast, l-arginine at 10 mg/min significantly (p < 0.01) augmented the forearm blood flow response to acetylcholine (4 to 24 μg/min) to a similar extent in the two groups. Conclusions. The effect of l-arginine on acetylcholine-induced vasodilation difers between the coronary and forearm vasculatures in humans. It is suggested that impaired acetylcholine-induced coronary and forearm vasodilation in patients with coronary artery disease and hypertension may not be related to a limited availability of l-arginine.

本文言語英語
ページ(範囲)948-955
ページ数8
ジャーナルJournal of the American College of Cardiology
24
4
DOI
出版ステータス出版済み - 10月 1994
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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