The effect of low-molecular-weight fraction of water-soluble extract (WS-LMF) of an edible algae, Susabi-nori (Porphyra yezoensis), on cell proliferation was examined using various cancer cell lines. WS-LMF was found to inhibit proliferation of human HL-60 leukemia cells and mouse B16 melanoma cells. WS-LMF also inhibited proliferation of HL-60 cells in a dose-dependent manner and was cytotoxic at higher concentration (1000μg/mL). WS-LMF was further fractionated to methanol-soluble and -insoluble fractions. Each fraction inhibited proliferation of HL-60 cells at a different UV spectra, suggesting that multiple anti-proliferation factors toward HL-60 cells are present in WS-LMF.
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