Effect of low-molecular-weight fraction of Susabi-nori water-soluble extract on HL-60 cell proliferation

Keisuke Tsuge, Yayoi Watanabe, Norihide Maeda, Shin Ichi Abe, Toru Tsuruhashi, Takashi Yoshimura, Masahiro Yoshiki, Hirofumi Tachibana, Koji Yamada

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

The effect of low-molecular-weight fraction of water-soluble extract (WS-LMF) of an edible algae, Susabi-nori (Porphyra yezoensis), on cell proliferation was examined using various cancer cell lines. WS-LMF was found to inhibit proliferation of human HL-60 leukemia cells and mouse B16 melanoma cells. WS-LMF also inhibited proliferation of HL-60 cells in a dose-dependent manner and was cytotoxic at higher concentration (1000μg/mL). WS-LMF was further fractionated to methanol-soluble and -insoluble fractions. Each fraction inhibited proliferation of HL-60 cells at a different UV spectra, suggesting that multiple anti-proliferation factors toward HL-60 cells are present in WS-LMF.

本文言語英語
ページ(範囲)241-246
ページ数6
ジャーナルNippon Shokuhin Kagaku Kogaku Kaishi
54
5
DOI
出版ステータス出版済み - 8 1 2007

All Science Journal Classification (ASJC) codes

  • 食品科学

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