To compare the influences of the oral administration of conjugated linoleic acids (CLA) on behaviors and fatty acid composition of some tissues with those of linoleic acid (LA) and docosahexaenoic acid (DHA), mice (8-week old) were orally administered with oils containing high levels of CLA, DHA or LA for 4 weeks (6 days per week, 0.2 ml per day). Control group was administered with saline. Behavioral tests such as locomotor activity, swinf. test, elevated plus maze test and biting test were done on the commencement of the study (0 week) and 2 and 4 weeks after treatments. No significant changes were observed in all the parameters. Oral CLA increased the liver weight and reduced the epididymal white adipose tissue weight. The ratio of arachidonic acid to total fatty acids was significantly increased by LA and decreased by CLA compared with the control, especially in the liver. Small amounts of CLA were detected in the brain of mice administered with CLA or LA groups, but not detected in mice of the control and DHA groups. The level of DHA in the brain was not altered by DHA administration. It is concluded that oral administration of CLA influenced some tissues but not behaviours of mice at least after growth.
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