Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study

Y. Yonezawa, H. Hondo, K. Hashimoto, T. Matsumoto, M. Hirano, H. Uchimura, T. Kuroki

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

本文言語英語
ページ(範囲)235-240
ページ数6
ジャーナルJournal of Neural Transmission
94
3
DOI
出版ステータス出版済み - 10 1993

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 生物学的精神医学

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