Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study

Y. Yonezawa, H. Hondo, K. Hashimoto, T. Matsumoto, M. Hirano, H. Uchimura, T. Kuroki

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

元の言語英語
ページ(範囲)235-240
ページ数6
ジャーナルJournal of Neural Transmission
94
発行部数3
DOI
出版物ステータス出版済み - 10 1 1993

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Phencyclidine
Excitatory Amino Acids
Gyrus Cinguli
Microdialysis
Aspartic Acid
Glutamic Acid
N-Methyl-D-Aspartate Receptors

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study. / Yonezawa, Y.; Hondo, H.; Hashimoto, K.; Matsumoto, T.; Hirano, M.; Uchimura, H.; Kuroki, T.

:: Journal of Neural Transmission, 巻 94, 番号 3, 01.10.1993, p. 235-240.

研究成果: ジャーナルへの寄稿記事

Yonezawa, Y. ; Hondo, H. ; Hashimoto, K. ; Matsumoto, T. ; Hirano, M. ; Uchimura, H. ; Kuroki, T. / Effect of phencyclidine on endogeneous excitatory amino acid release from the rat anterior cingulate cortex - an in vivo microdialysis study. :: Journal of Neural Transmission. 1993 ; 巻 94, 番号 3. pp. 235-240.
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AU - Kuroki, T.

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