Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization.

Longliang Wu; Naohiko Shimada; Arihiro Kano; Atsushi Maruyama

doi:10.1093/nass/nrm037

Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization.

Longliang Wu, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

物質基盤化学部門

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

2 被引用数 (Scopus)

抄録

We have focused on design of biomaterials that are capable of engineering nucleic acids folding. In this study, we explored the effect of poly(L-lysine)-g-dextran, PLL-g-Dex, copolymer on hybridization kinetics of DNA. The hybridization kinetics was studied by using a fluorescence resonance energy transfer (FRET) assay in the absence and presence of the copolymer. The copolymer at nano molar concentration significantly accelerated the hybridization rate over 200-fold under physiologically relevant ionic conditions.

本文言語	英語
ページ（範囲）	73-74
ページ数	2
ジャーナル	Nucleic acids symposium series (2004)
号	51
DOI	https://doi.org/10.1093/nass/nrm037
出版ステータス	出版済み - 2007

!!!All Science Journal Classification (ASJC) codes

医学（全般）

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10.1093/nass/nrm037

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abstract = "We have focused on design of biomaterials that are capable of engineering nucleic acids folding. In this study, we explored the effect of poly(L-lysine)-g-dextran, PLL-g-Dex, copolymer on hybridization kinetics of DNA. The hybridization kinetics was studied by using a fluorescence resonance energy transfer (FRET) assay in the absence and presence of the copolymer. The copolymer at nano molar concentration significantly accelerated the hybridization rate over 200-fold under physiologically relevant ionic conditions.",

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AB - We have focused on design of biomaterials that are capable of engineering nucleic acids folding. In this study, we explored the effect of poly(L-lysine)-g-dextran, PLL-g-Dex, copolymer on hybridization kinetics of DNA. The hybridization kinetics was studied by using a fluorescence resonance energy transfer (FRET) assay in the absence and presence of the copolymer. The copolymer at nano molar concentration significantly accelerated the hybridization rate over 200-fold under physiologically relevant ionic conditions.

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Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization.

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!!!All Science Journal Classification (ASJC) codes

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