Effect of poly(L-lysine)-g-dextran copolymers on DNA hybridization.

Longliang Wu, Naohiko Shimada, Arihiro Kano, Atsushi Maruyama

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

We have focused on design of biomaterials that are capable of engineering nucleic acids folding. In this study, we explored the effect of poly(L-lysine)-g-dextran, PLL-g-Dex, copolymer on hybridization kinetics of DNA. The hybridization kinetics was studied by using a fluorescence resonance energy transfer (FRET) assay in the absence and presence of the copolymer. The copolymer at nano molar concentration significantly accelerated the hybridization rate over 200-fold under physiologically relevant ionic conditions.

本文言語英語
ページ(範囲)73-74
ページ数2
ジャーナルNucleic acids symposium series (2004)
51
DOI
出版ステータス出版済み - 2007

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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