Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over

Yasuyo Abe, Takayuki Nishimura, Kazuhiko Arima, Mitsuo Kanagae, Satoshi Mizukami, Yoshihito Tomita, Takuhiro Okabe, Hisashi Goto, Itsuko Horiguchi, Kiyoshi Aoyagi

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Background: This study aimed to examine the association of walking difficulty with bone mass or bone turnover among community-dwelling Japanese people aged 40 years and older. Methods: We studied 1097 community-dwelling Japanese people aged 40 years and older (379 men and 718 women) who were invited to participate in periodic health examinations in 2006-2009. Walking difficulty was defined as having difficulty walking 100 m on a level surface (self-administered questionnaire). Calcaneal stiffness index (bone mass) was measured by quantitative ultrasound. Spot urine samples were collected, and urinary N-terminal cross-linking telopeptide of type I collagen (NTx) was measured. Values were corrected for creatinine (Cre) concentration. Results: The prevalence of walking difficulty was significantly higher in women than in men (7.4 vs. 3.4 %, p = 0.011) and significantly increased with age in men (p for trend = 0.02) and women (p for trend <0.001). In univariate analysis, men and women with walking difficulty were older (p < 0.001) and had a lower stiffness index (p < 0.001), compared with those without walking difficulty. Among women, individuals with walking difficulty had significantly higher urinary NTx/Cre than those without walking difficulty (p < 0.001); however, this was not so among men (p = 0.39). Multiple regression analysis adjusted for age, weight, and menopausal status showed a significant association between walking difficulty and lower stiffness index in men (p = 0.004) and women (p = 0.005). In women, walking difficulty was significantly associated with higher NTx/Cre (p = 0.001), but not in men (p = 0.35). Conclusions: Walking difficulty may contribute to low bone mass in both sexes but might cause high bone turnover in women only.

本文言語英語
論文番号25
ジャーナルJournal of physiological anthropology
35
1
DOI
出版ステータス出版済み - 1月 13 2016
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 人的要因と人間工学
  • 生理学
  • 整形外科およびスポーツ医学
  • 人類学
  • 公衆衛生学、環境および労働衛生
  • 生理学(医学)

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