Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice

Y. Yoshikai, S. Miake, T. Matsumoto, K. Nomoto, K. Takeya

    研究成果: Contribution to journalArticle

    45 引用 (Scopus)

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    The delayed footpad reaction to sheep erythrocytes (SRBC) was studied in mice whose mononuclear phagocyte system (MPS) was blocked or stimulated. Colloidal carbon or carrageenan was used for the blockade of MPS and Corynebacterium parvum or diethylstilbestrol used for the stimulation. The optimal dose of SRBC for the induction of the delayed footpad reaction was lower in MPS-blocked mice than in non-treated mice, whereas a high dose of SRBC was required for the induction of the strongest delayed footpad reaction in MPS-stimulated mice. These results suggest that non-specific phagocytic function of MPS modulates subsequent immune responses after administration of antigens.

    元の言語英語
    ページ(範囲)577-583
    ページ数7
    ジャーナルImmunology
    38
    発行部数3
    出版物ステータス出版済み - 1979

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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    Yoshikai, Y., Miake, S., Matsumoto, T., Nomoto, K., & Takeya, K. (1979). Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction to SRBC in mice. Immunology, 38(3), 577-583.