Effect of strontium doping on bone nodule formation of sol-gel derived bioglass

T. T. Swe, K. A. Shariff, A. F.M. Noor, K. Ishikawa, M. Hasmaliza

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Bioactive glass (BG) has a broad variety of biomedical applications because of its distinctive ability to bond with bone by exchanging ions in simulated body fluid when implanted inside the body, it has drawn enormous interest. Osteoporosis is a main cause of loss of bone density and that adding strontium (Sr) to the matrix of bioglass stimulates bone formation and also increases bone density and mass. This study concerns sol-gel derived Sr doped bioactive glass (BG) (50.77SiO2-24.12Na2O-(23.39-x)CaO-xSrO-1.72P2O5) in the quaternary (SiO2-Na2O-CaO-P2O5) system (x=0, 3, 5 and 8 mol%).The effect of Sr on bone nodule-like formation was conducted by using Calcified Nodule Staining Kit (Cosmo Bio Co., Ltd) after 28 days culture with MC3T3-E1 osteoblast-like cells (Riken Cell Bank, Tokyo, Japan). In XRD, the amorphous peak is slightly shifted to lower 2?° value after SrO was incorporated into BG. Mineralization staining revealed that the larger area of mineralized nodules was detected on Sr (3) BG than others. These results suggest that BG with SrO 3% is a good candidate for bone tissue engineering with fast bone formation.

本文言語英語
ホスト出版物のタイトル3rd International Postgraduate Conference on Materials, Minerals and Polymer, MAMIP 2019
編集者Mariatti Jaafar, Nurulakmal Mohd. Sharif
出版社American Institute of Physics Inc.
ISBN(電子版)9780735420304
DOI
出版ステータス出版済み - 9 21 2020
イベント3rd International Postgraduate Conference on Materials, Minerals and Polymer, MAMIP 2019 - Penang, マレーシア
継続期間: 10 31 201911 1 2019

出版物シリーズ

名前AIP Conference Proceedings
2267
ISSN(印刷版)0094-243X
ISSN(電子版)1551-7616

会議

会議3rd International Postgraduate Conference on Materials, Minerals and Polymer, MAMIP 2019
Countryマレーシア
CityPenang
Period10/31/1911/1/19

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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