Effect of superoxide anion on contractility of aortic smooth muscle cells

Wei Cheng, Tetsuya Koyama, Masahiro Oike

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Aim: To investigate the changes of [Ca2+]i and contractility of aortic smooth muscle cells induced by superoxide anion. Methods: The aortic smooth muscle cells were primarily cultured. The effect of superoxide anion on [Ca2+]i was measured by a digital fluorescence microscopy system. Muscle contractility was analyzed by collagen gel contraction system. Results High-K+ and A-23187 -induced [Ca 2+]i elevated both in control and X/XO-treated cells. The net increment of [Ca2+]i was not significantly different between control and X/XO-treated cells (P > 0.05). Collagen gel contraction area in X/XO-treated cells induced by High-K+ and A-23187 was impaired from 18.32% ± 2.11% to 5.13% ± 0.45% (P < 0.01) and 17.16% ± 1.10% to 4.31% ± 0.04% (P < 0.01). Conclusion: The results demonstrate that superoxide anion attenuates smooth muscle contraction, whereas [Ca2+]i increased by these agents were not affected.

本文言語英語
ページ(範囲)1215-1217
ページ数3
ジャーナルChinese Pharmacological Bulletin
28
9
DOI
出版ステータス出版済み - 9月 2012

!!!All Science Journal Classification (ASJC) codes

  • 薬理学

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