Effect of the 2013 asco-cap her2 testing guideline on the management of ihc/her2 2+ invasive breast cancer

MAI YAMADA, MAKOTO KUBO, HIDETAKA YAMAMOTO, Nami Yamashita, MASAYA KAI, KAREN ZAGUIRRE, KAZUHISA KANESHIRO, AKIKO SHIMAZAKI, SAORI HAYASHI, HITOMI KAWAJI, MASAKI MORI, YOSHINAO ODA, MASAFUMI NAKAMURA

研究成果: Contribution to journalArticle査読

抄録

Background/Aim: With advances in anti-HER2 treatment and improved prognoses of HER2-positive breast cancer, the American Society of Clinical Oncology and the American Society of Pathologists (ASCO/CAP) have revised the HER2 diagnostic guidelines several times. We examined how to respond clinically to the revisions of the interpretation of the immunohistochemistry (IHC) method. Patients and Methods: We re-evaluated 254 patients diagnosed as HER2 IHC equivocal, who underwent fluorescence in situ hybridization (FISH) before and after the IHC diagnostic criteria update in 2013. Results: Twenty of 131 (15.3%) IHC equivocal cases by the ASCO/CAP 2007 guideline were IHC score 3+ and one of 20 (0.76%) was negative for FISH. Five of 123 (4.1%) IHC equivocal cases by the ASCO/CAP 2013 guideline were negative for IHC as per the 2007 guideline and four were positive for FISH. Conclusion: After revision of the ASCO/CAP 2013 guideline, 3.3% of HER2-negative cases before the revision should have received anti-HER2 treatment.

本文言語英語
ページ(範囲)4143-4149
ページ数7
ジャーナルAnticancer research
41
8
DOI
出版ステータス出版済み - 8 2021

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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