Effect of the neurotoxic dose of methamphetamine on gene expression of parkin and Pael-receptors in rat striatum

T. Nakahara, T. Kuroki, E. Ohta, T. Kajihata, H. Yamada, M. Yamanaka, K. Hashimoto, T. Tsutsumi, M. Hirano, H. Uchimura

研究成果: Contribution to journalArticle査読

13 被引用数 (Scopus)

抄録

We previously reported that haloperidol, a dopamine-D2 receptor antagonist, induced striatal expression of parkin gene, which mutations cause autosomal recessive juvenile parkinsonism. Because of an involvement of the parkin gene defect in selective degeneration of dopaminergic neurons, we herein examined the effect of the neurotoxic dose of methamphetamine (METH; 40mg/kg, i.p.) on gene expression of parkin and its substrate Pael-receptor (R) in the dopamine-rich areas of the rat brain, using reverse transcription-polymerase chain reaction. parkin mRNA levels in the striatum, but not in other regions, decreased at 1 and 2h and returned to the pre-drug basal levels at 4h after METH administration. METH also decreased Pael-R mRNA levels in the striatum and substantia nigra within 2h after METH, while haloperidol (2mg/kg, s.c.) increased Pael-R mRNA levels in the substantia nigra at 2h after administration. These results suggest that temporary suppression of gene expression of parkin and Pael-R may be associated with the METH-induced dopaminergic neurotoxicity. Taken together with our previous report, dopaminergic modulation of the expression of parkin and Pael-R genes in the nigro-striatal pathway may have significant implication for pathophysiology and treatment of parkinson disease.

本文言語英語
ページ(範囲)213-219
ページ数7
ジャーナルParkinsonism and Related Disorders
9
4
DOI
出版ステータス出版済み - 3 2003

All Science Journal Classification (ASJC) codes

  • 神経学
  • 老年医学
  • 臨床神経学

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